BAF155 Antibody (F-2): sc-48350

BAF155 Antibody (F-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects BAF155 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAF155 Antibody (F-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BAF155, also known as SRG3, plays a crucial role in the SWI/SNF chromatin remodeling complex, which is essential for the regulation of gene expression. BAF155 is involved in the ATP-dependent remodeling of nucleosomes, facilitating the activation of transcription by altering chromatin structure. The functional core of the SWI/SNF complex includes BAF155, along with other key subunits such as Brm, Brg-1, and Ini1, which work synergistically to enhance remodeling activity. BAF155 not only contributes to the structural integrity of the complex but also influences the recruitment of additional regulatory proteins, thereby modulating the accessibility of DNA to transcription factors. Understanding BAF155 and its interactions within the SWI/SNF complex is vital for elucidating the mechanisms of gene regulation and the potential implications in various diseases, including cancer, where chromatin remodeling plays a significant role in tumorigenesis.

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BAF155 Antibody (F-2) References:

1. Monoclonal antibodies reactive with the BAF155 (SMARCC1) and BAF170 (SMARCC2) components of human SWI/SNF-related complexes.  |  Wang, X., et al. 2005. Hybridoma (Larchmt). 24: 55-7. PMID: 15785210
2. Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells.  |  Schaniel, C., et al. 2009. Stem Cells. 27: 2979-91. PMID: 19785031
3. Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21(WAF1/CIP1) expression.  |  Ahn, J., et al. 2011. Oncogene. 30: 445-56. PMID: 20935679
4. Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene.  |  DelBove, J., et al. 2011. Epigenetics. 6: 1444-53. PMID: 22139574
5. A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice.  |  Harmacek, L., et al. 2014. Dev Neurobiol. 74: 483-97. PMID: 24170322
6. CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.  |  Wang, L., et al. 2014. Cancer Cell. 25: 21-36. PMID: 24434208
7. Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.  |  Narayanan, R., et al. 2018. iScience. 4: 109-126. PMID: 30240734
8. RBM15 Modulates the Function of Chromatin Remodeling Factor BAF155 Through RNA Methylation in Developing Cortex.  |  Xie, Y., et al. 2019. Mol Neurobiol. 56: 7305-7320. PMID: 31020615
9. A Coil-to-Helix Transition Serves as a Binding Motif for hSNF5 and BAF155 Interaction.  |  Han, J., et al. 2020. Int J Mol Sci. 21: PMID: 32244797
10. SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.  |  Allen, MD., et al. 2021. Commun Biol. 4: 528. PMID: 33953332

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BAF155 Antibody (F-2) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-BAF155 Antibody (F-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BAF155 Antibody (F-2) Specifications

Alternate Product Name: SMARCC1

Product Clone Name: F-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 998-1073

Epitope Target: BAF155

Epitope Species: human

Product Reactivity/Detection: BAF155

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for BAF155 Antibody (F-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred BAF155 antibody is BAF155 Antibody (DXD7): sc-32763.