Molecular structure of Azelaoyl-PAF, CAS Number: 354583-69-0
Azelaoyl-PAF (CAS 354583-69-0)
Alternate Names:
1-O-hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine
Application:
Azelaoyl-PAF is a PPARγ agonist
CAS Number:
354583-69-0
Molecular Weight:
651.85
Molecular Formula:
C33H66NO9P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Azelaoyl-PAF is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist which competes for the thiazoladinedione binding site. It is more potent than 15-deoxy-Δ12,14-prostaglandin J2 and equipotent with rosiglitazone (sc-202795) as a ligand for this receptor.
Azelaoyl-PAF (CAS 354583-69-0) References
- Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. | Davies, SS., et al. 2001. J Biol Chem. 276: 16015-23. PMID: 11279149
- Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. | Baek, SJ., et al. 2003. J Biol Chem. 278: 5845-53. PMID: 12475986
- Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. | Garg, TK. and Chang, JY. 2003. BMC Ophthalmol. 3: 5. PMID: 12659653
- Identification of lysophosphatidylcholine (LPC) and platelet activating factor (PAF) from PC12 cells and mouse cortex using liquid chromatography/multi-stage mass spectrometry (LC/MS3). | Smith, JC., et al. 2008. Rapid Commun Mass Spectrom. 22: 3579-87. PMID: 18937225
- PPAR-gamma agonist Azelaoyl PAF increases frataxin protein and mRNA expression: new implications for the Friedreich's ataxia therapy. | Marmolino, D., et al. 2009. Cerebellum. 8: 98-103. PMID: 19104905
- Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia. | Coppola, G., et al. 2009. Hum Mol Genet. 18: 2452-61. PMID: 19376812
- Anti-inflammatory peptides grab on to the whiskers of atherogenic oxidized lipids. | Epand, RF., et al. 2009. Biochim Biophys Acta. 1788: 1967-75. PMID: 19559666
- Current and emerging treatment options in the management of Friedreich ataxia. | Mancuso, M., et al. 2010. Neuropsychiatr Dis Treat. 6: 491-9. PMID: 20856912
- ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. | Doll, S., et al. 2017. Nat Chem Biol. 13: 91-98. PMID: 27842070
- Serum Metabolomics Reveals That Gut Microbiome Perturbation Mediates Metabolic Disruption Induced by Arsenic Exposure in Mice. | Xue, J., et al. 2019. J Proteome Res. 18: 1006-1018. PMID: 30628788
- Molecular signatures associated with prostate cancer cell line (PC-3) exposure to inactivated Zika virus. | Delafiori, J., et al. 2019. Sci Rep. 9: 15351. PMID: 31653965
- LimeMap: a comprehensive map of lipid mediator metabolic pathways. | Nishi, A., et al. 2021. NPJ Syst Biol Appl. 7: 6. PMID: 33504811
- Understanding modulations of lipid mediators in cancer using a murine model of carcinomatous peritonitis. | Kurano, M., et al. 2022. Cancer Med. 11: 3491-3507. PMID: 35315587
- CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin through modulation of PPAR-γ activity. | Ghodsian, N., et al. 2022. Free Radic Res. 56: 366-377. PMID: 36017639
Activator of:
PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Azelaoyl-PAF, 1 mg | sc-221278 | 1 mg | $200.00 | |||
Azelaoyl-PAF, 5 mg | sc-221278A | 5 mg | $440.00 |