Aprataxin Antibody (E-9): sc-393648
- Aprataxin Antibody (E-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 287-307 near the C-terminus of Aprataxin of human origin
- recommended for detection of Aprataxin isoforms 1-9 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-393648 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Aprataxin Antibody (E-9) for WB applications. These reagents are now offered in bundles with Aprataxin Antibody (E-9) (see ordering information below).
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SEE ALSO...
Aprataxin Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects Aprataxin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aprataxin is a crucial nuclear protein located in both the nucleoplasm and nucleolus, playing a vital role in DNA single-strand break repair. This function is essential for maintaining genomic stability and preventing DNA damage accumulation, which can lead to various diseases, including cancer. Aprataxin is a member of the histidine triad (HIT) superfamily and features three conserved domains: an N-terminal forkhead-associated (FHA) domain facilitating protein-protein interactions, a HIT domain sharing similarities with Hint, and a C-terminal zinc finger domain important for structural integrity and function. Mutations in the APTX gene, which encodes Aprataxin, can destabilize Aprataxin and lead to ataxia-oculomotor apraxia, a rare neurological disorder characterized by abnormal head and eye movements. These mutations often affect the HIT domain or result in truncation before the zinc finger, underscoring the importance of Aprataxin′s structural components in functionality and cellular health maintenance. Anti-Aprataxin antibody (E-9) is an invaluable tool for researchers studying DNA repair mechanisms and related pathologies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aprataxin Antibody (E-9) | sc-393648 | 200 µg/ml | $322.00 | |||
Aprataxin Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-538269 | 200 µg Ab; 10 µg BP | $361.00 | |||
Aprataxin Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-535846 | 200 µg Ab; 40 µg BP | $361.00 | |||
Aprataxin Antibody (E-9): m-IgG1 BP-HRP Bundle | sc-545613 | 200 µg Ab; 20 µg BP | $361.00 | |||
Aprataxin (E-9) Neutralizing Peptide | sc-393648 P | 100 µg/0.5 ml | $69.00 | |||
Aprataxin Antibody (E-9) X | sc-393648 X | 200 µg/0.1 ml | $322.00 |