Molecular structure of API-1, CAS Number: 36707-00-3
API-1 (CAS 36707-00-3)
Alternate Names:
4-amino-8-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Application:
API-1 is a PKB inhibitor that halts Akt membrane translocation
CAS Number:
36707-00-3
Molecular Weight:
337.29
Molecular Formula:
C13H15N5O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
API-1 is a PKB inhibitor. The compound acts by halting Akt membrane translocation through binding the pleckstrin homology domain of Akt. API-1 also inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Both in vivo and in vitro antitumor activity has been observed along with cell arrest and apoptosis in cancer cells with constitutive Akt activity.
API-1 (CAS 36707-00-3) References
- A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. | Kim, D., et al. 2010. J Biol Chem. 285: 8383-94. PMID: 20068047
- The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition. | Li, B., et al. 2012. Cancer Prev Res (Phila). 5: 612-20. PMID: 22345097
- The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. | Ren, H., et al. 2013. Mol Cancer. 12: 146. PMID: 24261825
- PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis. | Lopes-Pires, ME., et al. 2015. PLoS One. 10: e0137901. PMID: 26375024
- Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells. | Saglam, AS., et al. 2016. Oncol Lett. 12: 2463-2474. PMID: 27698814
- Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development. | Pu, W., et al. 2018. Hepatology. 68: 547-560. PMID: 29381806
- α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). | Karaboğa Arslan, AK. and Yerer, MB. 2018. Nutrients. 10: PMID: 29799481
- MicroRNA Biogenesis is Enhanced by Liposome-Encapsulated Pin1 Inhibitor in Hepatocellular Carcinoma. | Sun, D., et al. 2019. Theranostics. 9: 4704-4716. PMID: 31367251
- GSI Treatment Preserves Protein Synthesis in C2C12 Myotubes. | Huot, JR., et al. 2021. Cells. 10: PMID: 34359954
- Pin1 inhibitor API-1 sensitizes BRAF-mutant thyroid cancers to BRAF inhibitors by attenuating HER3-mediated feedback activation of MAPK/ERK and PI3K/AKT pathways. | Dang, H., et al. 2023. Int J Biol Macromol. 248: 125867. PMID: 37473892
Inhibitor of:
Akt, and API5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
API-1, 10 mg | sc-361106 | 10 mg | $275.00 |