AP-2γ Antibody (AP2g 6E4/4): sc-53162

AP-2γ Antibody (AP2g 6E4/4) is a mouse monoclonal IgG1 kappa light chain antibody that detects AP-2γ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. AP-2γ is a crucial member of the AP-2 transcription factor family, which also includes AP-2α and AP-2β, and binds to the DNA consensus sequence CCCCAGGC to initiate transcription of specific genes. AP-2γ protein is primarily located in the nucleus, where AP-2γ (AP2g 6E4/4) antibody plays a vital role in regulating gene expression related to cell growth and differentiation. Nuclear localization of AP-2γ is essential for function as a transcription factor, allowing interaction with various gene promoters and modulating expression of genes involved in critical cellular processes. AP-2γ monoclonal antibody (AP2g 6E4/4) helps researchers study AP-2γ′s role in regulating the proto-oncogene c-ErbB-2, which is overexpressed in many breast cancers. Additionally, AP-2γ functions as part of the OB2-1 transcription factor complex, influencing genes involved in tumorigenesis. Understanding AP-2γ′s function and localization is crucial for elucidating its role in both normal cellular processes and disease states, making anti-AP-2γ antibody (AP2g 6E4/4) an invaluable tool for researchers studying gene regulation and cancer biology.

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AP-2γ Antibody (AP2g 6E4/4) References:

1. Differential expression of AP-2gamma and AP-2alpha during human trophoblast differentiation.  |  Richardson, BD., et al. 2001. Life Sci. 69: 2157-65. PMID: 11669459
2. AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells.  |  Li, H., et al. 2006. Oncogene. 25: 5405-15. PMID: 16636674
3. AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells.  |  Li, H., et al. 2006. Neoplasia. 8: 568-77. PMID: 16867219
4. AP-2γ regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription.  |  Tan, SK., et al. 2011. EMBO J. 30: 2569-81. PMID: 21572391
5. Ontogenesis of Ap-2γ expression in rat testes.  |  Hou, M., et al. 2011. Sex Dev. 5: 188-96. PMID: 21654158
6. Expression of AP-2γ in placentas of patients with preeclampsia and of smokers.  |  Schneider, HA., et al. 2015. Arch Gynecol Obstet. 291: 1015-21. PMID: 25315380
7. Identification of a Wells-Dawson polyoxometalate-based AP-2γ inhibitor with pro-apoptotic activity.  |  Hu, J., et al. 2018. Biochem J. 475: 1965-1977. PMID: 29760237
8. WWOX Loses the Ability to Regulate Oncogenic AP-2γ and Synergizes with Tumor Suppressor AP-2α in High-Grade Bladder Cancer.  |  Kołat, D., et al. 2021. Cancers (Basel). 13: PMID: 34204827
9. Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2α and AP-2γ Transcription Factors in Bladder Cancer.  |  Kołat, D., et al. 2022. Cells. 11: PMID: 35563688
10. HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma.  |  Zeng, TT., et al. 2022. Cell Death Dis. 13: 1026. PMID: 36476988

The preferred AP-2γ antibody is AP-2γ Antibody (6E4/4): sc-12762.