AP-2β Antibody (G-7): sc-390135
- AP-2β Antibody (G-7) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against amino acids 130-216 of AP-2β of human origin
- recommended for detection of AP-2β of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and bovine
- TransCruz reagent for ChIP application (sc-390135 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AP-2β Antibody (G-7). This work is in progress.
AP-2β Antibody (G-7) is a mouse monoclonal IgM antibody that detects AP-2β in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AP-2β, a splice variant of the AP-2α transcription factor, plays a crucial role in regulating gene expression by binding to specific DNA sequences, thereby influencing various biological processes, including cell differentiation and proliferation. AP-2β (G-7) antibody has proven particularly significant in cancer biology research, as AP-2β inhibits AP-2α activity, which can lead to altered expression of genes involved in tumorigenesis. AP-2β functions as part of the OB2-1 transcription factor complex, responsible for upregulating the proto-oncogene c-ErbB-2, a gene overexpressed in 25-30% of breast cancers, highlighting AP-2β′s potential role in oncogenic pathways. Deleterious mutations in AP-2β have been associated with developmental disorders, underscoring AP-2β′s importance in both normal physiology and disease states. AP-2β (G-7) monoclonal antibody provides a valuable tool for researchers investigating complex regulatory networks involving AP-2 family members and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
AP-2β Antibody (G-7) References:
- GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation. | Ding, X., et al. 2006. Nucleic Acids Res. 34: 2570-8. PMID: 16698963
- Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2beta. | Hong, SJ., et al. 2008. J Biol Chem. 283: 16860-7. PMID: 18424435
- Transcription factor AP-2β regulates the neurotransmitter phenotype and maturation of chromaffin cells. | Hong, SJ., et al. 2011. Mol Cell Neurosci. 46: 245-51. PMID: 20875861
- The transcription factors AP-2β and AP-2α are required for survival of sympathetic progenitors and differentiated sympathetic neurons. | Schmidt, M., et al. 2011. Dev Biol. 355: 89-100. PMID: 21539825
- AP-2β enhances p53-mediated transcription of the αB-crystallin gene through stabilizing p53. | Hu, X., et al. 2012. Mol Biol Rep. 39: 209-14. PMID: 21556774
- AP-2β regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes. | Rossello, XS., et al. 2012. Brain Res. 1444: 87-95. PMID: 22325097
- AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development. | Chen, L., et al. 2016. Invest Ophthalmol Vis Sci. 57: 1072-81. PMID: 26968737
- Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2β. | Raap, M., et al. 2018. Lab Invest. 98: 117-129. PMID: 29035379
- DHX33 Interacts with AP-2β To Regulate Bcl-2 Gene Expression and Promote Cancer Cell Survival. | Wang, J., et al. 2019. Mol Cell Biol. 39: PMID: 31182639
- Conditional Deletion of AP-2β in the Periocular Mesenchyme of Mice Alters Corneal Epithelial Cell Fate and Stratification. | Walker, H., et al. 2021. Int J Mol Sci. 22: PMID: 34445433
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AP-2β Antibody (G-7) | sc-390135 | 200 µg/ml | $322.00 | |||
AP-2β Antibody (G-7) X | sc-390135 X | 200 µg/0.1 ml | $322.00 |