Molecular structure of Amifostine Thiol Dihydrochloride, CAS Number: 14653-77-1
Amifostine Thiol Dihydrochloride (CAS 14653-77-1)
Alternate Names:
2-[(3-Aminopropyl)amino]ethanethiol Hydrochloride; WR 1065
Application:
Amifostine Thiol Dihydrochloride is a metabolite of Amifostine
CAS Number:
14653-77-1
Molecular Weight:
207.16
Molecular Formula:
C5H16Cl2N2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Amifostine Thiol Dihydrochloride is a metabolite of Amifostine.Amifostine is a dihydrochloride compound containing a thiol group, which is utilized to safeguard normal tissues from the harmful effects of ionizing radiation. Acting as an antioxidant, it exhibits potential protective properties against radiation-induced damage. Amifostine has demonstrated effectiveness in optimizing tissue culture, as well as protecting muscle and intestinal cells from radiation. In vitro studies, amifostine may act to activate DNA repair enzymes, resulting in increased DNA and RNA synthesis. Furthermore, its active metabolite has been observed to impede bacterial growth by binding to ribosomes and inhibiting protein synthesis.
Amifostine Thiol Dihydrochloride (CAS 14653-77-1) References
- Further evidence that the radioprotective aminothiol, WR-1065, catalytically inactivates mammalian topoisomerase II. | Snyder, RD. and Grdina, DJ. 2000. Cancer Res. 60: 1186-8. PMID: 10728671
- Relationships between cytoprotection and mutation prevention by WR-1065. | Grdina, DJ., et al. 2002. Mil Med. 167: 51-3. PMID: 11873516
- WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. | Dziegielewski, J., et al. 2008. Free Radic Biol Med. 45: 1674-81. PMID: 18845240
- Radioprotection in mice following oral administration of WR-1065/PLGA nanoparticles. | Pamujula, S., et al. 2008. Int J Radiat Biol. 84: 900-8. PMID: 19016138
- The effect of the radioprotector WR-2721 and WR-1065 on mitochondrial lipid peroxidation. | Tretter, L., et al. 1990. Int J Radiat Biol. 57: 467-78. PMID: 1968940
- Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721. | Calabro-Jones, PM., et al. 1985. Int J Radiat Biol Relat Stud Phys Chem Med. 47: 23-7. PMID: 2982751
- Measurement of WR-2721, WR-1065, and WR-33278 in plasma. | Fahey, RC. and Newton, GL. 1985. Int J Radiat Oncol Biol Phys. 11: 1193-7. PMID: 2987166
- Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721. | Utley, JF., et al. 1984. Int J Radiat Oncol Biol Phys. 10: 1525-8. PMID: 6090355
- Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: implications for mechanisms of radioprotection. | Purdie, JW., et al. 1983. Int J Radiat Biol Relat Stud Phys Chem Med. 43: 517-27. PMID: 6303973
- Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse. | Shaw, LM., et al. 1994. Drug Metab Dispos. 22: 895-902. PMID: 7895607
- Concentration-dependent protection against X-ray-induced chromosome aberrations in human lymphocytes by the aminothiol WR-1065. | Littlefield, LG., et al. 1993. Radiat Res. 133: 88-93. PMID: 8434118
- WR-1065 and radioprotection of vascular endothelial cells. I. Cell proliferation, DNA synthesis and damage. | Rubin, DB., et al. 1996. Radiat Res. 145: 210-6. PMID: 8606931
- WR-1065 and radioprotection of vascular endothelial cells. II. Morphology. | Mooteri, SN., et al. 1996. Radiat Res. 145: 217-24. PMID: 8606932
Inhibitor of:
cep-1, p67-phox, and USP53.Activator of:
p53.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amifostine Thiol Dihydrochloride, 10 mg | sc-210796 | 10 mg | $143.00 | |||
Amifostine Thiol Dihydrochloride, 50 mg | sc-210796A | 50 mg | $595.00 | |||
Amifostine Thiol Dihydrochloride, 100 mg | sc-210796B | 100 mg | $1122.00 | |||
Amifostine Thiol Dihydrochloride, 500 mg | sc-210796C | 500 mg | $5100.00 | |||
Amifostine Thiol Dihydrochloride, 1 g | sc-210796D | 1 g | $8670.00 | |||
Amifostine Thiol Dihydrochloride, 5 g | sc-210796E | 5 g | $24480.00 |