Date published: 2026-5-6

1-800-457-3801

SCBT Portrait Logo
Seach Input

α-Zearalenol (CAS 36455-72-8)

4.0(1)
Write a reviewAsk a question

See product citations (1)

Application:
α-Zearalenol is an estrogenic synthetic derivative of the Zeralenone mycotoxin
CAS Number:
36455-72-8
Purity:
>99%
Molecular Weight:
320.3
Molecular Formula:
C18H24O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

α-Zearalenol is a synthetic derivative of the macrolactone mycotoxin zearalenone (sc-204943) found in Fusarium roseum fungus. α-Zearalenol is estrogenically active and demonstrates induction of premature uterine growth, increase of nuclear estrogen receptor levels, and a five fold increase of ornithine decarboxylase level (ODC). The increase of ODC level was 20-fold more pronounced with α-zearalenol than zearalenone, and α-Zearalenol demonstrated three times more potent estrogenic activity than zearalenone. α-Zearalenol, a synthetic derivative of the macrolactone mycotoxin zearalenone, is a significant hepatic metabolite produced in response to the presence of zearalenone, a mycotoxin produced by fungi found in both food and animal feeds.


α-Zearalenol (CAS 36455-72-8) References

  1. The phytoestrogen alpha-zearalenol reverses endothelial dysfunction induced by oophorectomy in rats.  |  Altavilla, D., et al. 2001. Lab Invest. 81: 125-32. PMID: 11232633
  2. Incidence of zearalenol (Fusarium mycotoxin) in animal feed.  |  Mirocha, CJ., et al. 1979. Appl Environ Microbiol. 38: 749-50. PMID: 161492
  3. Effects of four Fusarium toxins (fumonisin B(1), alpha-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation.  |  Luongo, D., et al. 2008. Toxicon. 52: 156-62. PMID: 18620720
  4. Mycotoxin alpha-zearalenol impairs the quality of preimplantation porcine embryos.  |  Wang, H., et al. 2012. J Reprod Dev. 58: 338-43. PMID: 22447324
  5. Dispositions and tissue residue of zearalenone and its metabolites α-zearalenol and β-zearalenol in broilers.  |  Buranatragool, K., et al. 2015. Toxicol Rep. 2: 351-356. PMID: 28962368
  6. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells.  |  Tatay, E., et al. 2018. Toxicol Mech Methods. 28: 239-242. PMID: 29057713
  7. Alpha-zearalenol negatively influences ram sperm parameters during liquid storage.  |  Abbaszadeh, S., et al. 2018. Vet Res Forum. 9: 171-178. PMID: 30065806
  8. Zearalenone and ß-Zearalenol But Not Their Glucosides Inhibit Heat Shock Protein 90 ATPase Activity.  |  Torres Acosta, JA., et al. 2019. Front Pharmacol. 10: 1160. PMID: 31680951
  9. Quantification of zearalenone and α-zearalenol in swine liver and reproductive tissues using GC-MS.  |  Pack, E., et al. 2020. Toxicon X. 8: 100058. PMID: 33089147
  10. Biomarkers of Exposure to Zearalenone in In Vivo and In Vitro Studies.  |  Llorens, P., et al. 2022. Toxins (Basel). 14: PMID: 35622538
  11. Identification of the naturally occurring isomer of zearalenol produced by Fusarium roseum 'Gibbosum' in rice culture.  |  Hagler, WM., et al. 1979. Appl Environ Microbiol. 37: 849-53. PMID: 485136
  12. Estrogenic activity of zearalenone and zearalanol in the neonatal rat uterus.  |  Sheehan, DM., et al. 1984. Teratology. 29: 383-92. PMID: 6235618
  13. Transformation of zearalenone and zearalenol by rat erythrocytes.  |  Chang, WM. and Lin, JK. 1984. Food Chem Toxicol. 22: 887-91. PMID: 6238883
  14. Binding properties of zearalenone mycotoxins to hepatic estrogen receptors.  |  Powell-Jones, W., et al. 1981. Mol Pharmacol. 20: 35-42. PMID: 6457245

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

α-Zearalenol, 5 mg

sc-202388
5 mg
$268.00