alpha Synuclein Antibody (3G282): sc-69978

α-synuclein Antibody (3G282) is a mouse monoclonal IgG1 kappa light chain antibody developed to detect α-synuclein, also known as SNCA or NACP, in human samples using western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP) techniques. α-synuclein monoclonal antibody (3G282) targets α-synuclein associated with Lewy bodies, which are pathological aggregates found in the brains of individuals with neurodegenerative diseases such as Parkinson′s disease and Alzheimer′s disease. α-synuclein is predominantly expressed in neuronal cell bodies and synapses, where α-synuclein plays a critical role in regulating synaptic vesicle trafficking and neurotransmitter release, essential for effective neuronal communication and plasticity. α-synuclein interacts with several key proteins, including synaptobrevin, which is involved in vesicle fusion, and synphilin-1, which modulates α-synuclein aggregation and stability. Additionally, α-synuclein interacts with tau protein, influencing microtubule dynamics and contributing to neuronal structure and function. These interactions are vital for maintaining synaptic integrity and neuronal health, and disruptions can lead to impaired neurotransmission and contribute to the development of neurodegenerative disorders. Understanding α-synuclein interactions with these proteins is crucial for elucidating the molecular mechanisms underlying synucleinopathies and identifying potential therapeutic targets. α-synuclein (3G282) antibody is available in an unconjugated form, providing flexibility for various experimental applications. α-synuclein (3G282) monoclonal antibody is an essential tool for scientists dedicated to unraveling the intricate roles of α-synuclein in maintaining neuronal function and contribution to the pathogenesis of synuclein-related disorders.

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.