ACTR5 Antibody (F-12): sc-376364
- ACTR5 Antibody (F-12) is a mouse monoclonal IgG1 κ ACTR5 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 39-71 near the N-terminus of ACTR5 of human origin
- ACTR5 Antibody (F-12) is recommended for detection of ACTR5 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ACTR5 Antibody (F-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ACTR5 Antibody (F-12) for WB applications. These reagents are now offered in bundles with ACTR5 Antibody (F-12) (see ordering information below).
ACTR5 Antibody (F-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects ACTR5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACTR5 (F-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACTR5, also known as actin-related protein 5 or INO80M, consists of 607 amino acids and is a crucial component of the INO80 chromatin remodeling complex, which plays a significant role in gene expression regulation. ACTR5′s ability to interact with other actin-related proteins is vital for function in transcriptional regulation, as ACTR5 helps remodel chromatin structure, thereby influencing DNA accessibility to transcription factors and other regulatory proteins. The gene encoding ACTR5 is located on chromosome 20, which comprises approximately 2% of the human genome and contains over 600 genes associated with various diseases, including Creutzfeldt-Jakob disease and amyotrophic lateral sclerosis. Understanding ACTR5′s function and interactions is essential for elucidating roles in cellular processes and potential implications in disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ACTR5 Antibody (F-12) References:
- Gerstmann-Sträussler-Scheinker syndrome,fatal familial insomnia, and kuru: a review of these less common human transmissible spongiform encephalopathies. | Collins, S., et al. 2001. J Clin Neurosci. 8: 387-97. PMID: 11535002
- Involvement of actin-related proteins in ATP-dependent chromatin remodeling. | Shen, X., et al. 2003. Mol Cell. 12: 147-55. PMID: 12887900
- Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. | van Attikum, H., et al. 2004. Cell. 119: 777-88. PMID: 15607975
- A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. | Jin, J., et al. 2005. J Biol Chem. 280: 41207-12. PMID: 16230350
- Early pattern of epilepsy in the ring chromosome 20 syndrome. | Ville, D., et al. 2006. Epilepsia. 47: 543-9. PMID: 16529619
- The INO80 complex is required for damage-induced recombination. | Kawashima, S., et al. 2007. Biochem Biophys Res Commun. 355: 835-41. PMID: 17320816
- The INO80 chromatin remodeling complex functions in sister chromatid cohesion. | Ogiwara, H., et al. 2007. Cell Cycle. 6: 1090-5. PMID: 17471029
- Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex. | Yu, EY., et al. 2007. Mol Cell Biol. 27: 5639-49. PMID: 17562861
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACTR5 Antibody (F-12) | sc-376364 | 200 µg/ml | $322.00 | |||
ACTR5 Antibody (F-12): m-IgG Fc BP-HRP Bundle | sc-529857 | 200 µg Ab; 10 µg BP | $361.00 | |||
ACTR5 Antibody (F-12): m-IgGκ BP-HRP Bundle | sc-522927 | 200 µg Ab, 40 µg BP | $361.00 | |||
ACTR5 Antibody (F-12): m-IgG1 BP-HRP Bundle | sc-543727 | 200 µg Ab; 20 µg BP | $361.00 | |||
ACTR5 Antibody (F-12) AC | sc-376364 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ACTR5 Antibody (F-12) HRP | sc-376364 HRP | 200 µg/ml | $322.00 | |||
ACTR5 Antibody (F-12) FITC | sc-376364 FITC | 200 µg/ml | $336.00 | |||
ACTR5 Antibody (F-12) PE | sc-376364 PE | 200 µg/ml | $349.00 | |||
ACTR5 Antibody (F-12) Alexa Fluor® 488 | sc-376364 AF488 | 200 µg/ml | $364.00 | |||
ACTR5 Antibody (F-12) Alexa Fluor® 546 | sc-376364 AF546 | 200 µg/ml | $364.00 | |||
ACTR5 Antibody (F-12) Alexa Fluor® 594 | sc-376364 AF594 | 200 µg/ml | $364.00 | |||
ACTR5 Antibody (F-12) Alexa Fluor® 647 | sc-376364 AF647 | 200 µg/ml | $364.00 | |||
ACTR5 Antibody (F-12) Alexa Fluor® 680 | sc-376364 AF680 | 200 µg/ml | $364.00 | |||
ACTR5 Antibody (F-12) Alexa Fluor® 790 | sc-376364 AF790 | 200 µg/ml | $364.00 | |||
ACTR5 (F-12) Neutralizing Peptide | sc-376364 P | 100 µg/0.5 ml | $69.00 |