4E-BP1 (FL): sc-4251
- intera proteina 4E-BP-1 (PHAS-1) di origine ratto corrispondente agli aminoacidi 1-117; 50 µg
- produced in E. coli as 21 kDa polyhistidine tagged fusion protein
- substrate for FRAP and MAP kinases
- Western blotting control for sc-9977
The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.
Informazioni ordini
| Nome del prodotto | Codice del prodotto | UNITÀ | Prezzo | Quantità | Preferiti | |
4E-BP1 (FL) | sc-4251 | 50 µg | $188.00 |