YTHDF2 Activators
YTHDF2 activators are chemical compounds that can influence the activity of the YTHDF2 protein, a key player in the regulation of m6A-modified RNA molecules. These activators work through various mechanisms to enhance the role of YTHDF2 in RNA metabolism. Among the compounds listed, several can be considered YTHDF2 activators based on their known effects on the pathways and processes that intersect with YTHDF2 function.
Firstly, 3-Deazaadenosine stands out as a potential YTHDF2 activator due to its ability to modulate adenosine-related pathways. Adenosine is a fundamental component of m6A methylation, a modification recognized by YTHDF2. By influencing adenosine metabolism, 3-Deazaadenosine can potentially enhance the availability of m6A-modified RNA substrates, thereby promoting YTHDF2 binding and downstream regulatory actions. Additionally, compounds like RG108, 5-Aza-2'-deoxycytidine, and S-Adenosyl Methionine (SAM) indirectly affect YTHDF2 by targeting DNA methyltransferases. These enzymes are involved in DNA and RNA modifications, and alterations in their activity can lead to changes in the epigenetic landscape that includes m6A modifications. YTHDF2 activators of this class may facilitate the generation or recognition of m6A marks on RNA, bolstering YTHDF2-mediated RNA regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D inhibits RNA polymerase, potentially altering RNA transcription dynamics, indirectly affecting YTHDF2 interactions. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor that can modulate cellular signaling pathways, which may intersect with YTHDF2 regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, impacting m6A methylation and translation processes, which may indirectly affect YTHDF2-mediated RNA regulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine is a DNA methyltransferase inhibitor that can indirectly affect DNA and RNA modifications, potentially influencing YTHDF2 activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid is an HDAC inhibitor that can modulate chromatin and gene expression, potentially influencing YTHDF2 expression levels. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is known to inhibit RNA helicases, which might interfere with RNA secondary structure dynamics, impacting YTHDF2 interactions. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin can influence RNA decay pathways and may indirectly impact YTHDF2-mediated RNA degradation processes. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits translation initiation factors, potentially affecting protein synthesis, which might indirectly impact YTHDF2. | ||||||