tropomodulin 3 Activators
Tropomodulin 3 (Tmod3) activators belong to a specific class of chemical compounds designed to interact with and modulate the activity of tropomodulin 3 proteins within the cellular context. Tropomodulins are a family of actin-regulatory proteins found in various tissues, including muscle and erythrocytes. These proteins play a crucial role in regulating actin filament dynamics, which are essential for maintaining the structural integrity and functionality of cells. Tropomodulin 3, specifically, is predominantly expressed in cardiac and skeletal muscle tissues, where it is involved in the regulation of actin filament lengths within the sarcomeres. Tmod3 activators are designed to enhance the binding and stabilizing effects of Tmod3 on actin filaments, contributing to the precise control of actin polymerization and depolymerization within muscle cells.
The mechanism of action of Tmod3 activators typically involves increasing the affinity of Tmod3 for actin filaments, leading to enhanced capping and stabilizing of actin filament ends. This, in turn, promotes the proper assembly and maintenance of the sarcomeric structure in muscle cells, ensuring efficient contraction and relaxation cycles. Tmod3 activators have garnered interest in the field of cell biology and muscle physiology due to their potential to modulate actin dynamics in a highly specific and controlled manner.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Promotes TMOD3 activation by stabilizing actin filaments, preventing their depolymerization. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Induces TMOD3 activation by capping the fast-growing end of actin filaments, enhancing actin polymerization. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Activates TMOD3 by sequestering actin monomers, preventing their polymerization into filaments. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Activates TMOD3 through binding to and stabilizing actin filaments, thereby influencing actin filament properties. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Enhances TMOD3 activation by inhibiting myosin II activity, indirectly impacting actin dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Facilitates TMOD3 activation by selectively inhibiting Rho-associated protein kinase (ROCK), indirectly affecting actin and potentially TMOD3. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Promotes TMOD3 activation by inhibiting the Arp2/3 complex, which influences actin dynamics. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Activates TMOD3 by disrupting formin-mediated actin polymerization, indirectly affecting actin filaments. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
Enhances TMOD3 activation as another Arp2/3 complex inhibitor, influencing actin dynamics and potentially affecting TMOD3. | ||||||