TBC1D3B Activators
TBC1D3B activators represent a class of chemical compounds that have garnered significant attention in the realm of cellular and molecular biology. TBC1D3B, short for Tre-2/Bub2/Cdc16 domain family member 3B, is a protein-coding gene found in humans. This gene encodes a member of the TBC1 domain family, which is involved in regulating intracellular trafficking and vesicular transport. The activators specifically target the TBC1D3B protein, modulating its activity.
TBC1D3B activators exert their effects by binding to the TBC1D3B protein, leading to changes in its conformation and subsequent alterations in its cellular functions. While the exact mechanisms of TBC1D3B activation are still under investigation, it is believed that these compounds play a crucial role in regulating various intracellular processes, such as vesicle trafficking, membrane dynamics, and signal transduction pathways. By modulating the activity of TBC1D3B, these activators may influence the sorting and transport of cellular components, which can impact cellular homeostasis and function. Studying these compounds provides valuable insights into the intricate regulatory mechanisms governing cellular processes, shedding light on the broader field of cell biology and molecular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $57.00 $72.00 $126.00 | 7 | |
Rutin activates TBC1D3B by modulating the PI3K/Akt signaling pathway. It inhibits PI3K activity, leading to decreased phosphorylation of Akt. This inhibition relieves the suppressive effect of Akt on TBC1D3B, resulting in its activation. Therefore, rutin indirectly activates TBC1D3B through modulation of the PI3K/Akt pathway. | ||||||
Diosmin | 520-27-4 | sc-204728 sc-204728A | 5 g 25 g | $58.00 $114.00 | 2 | |
Diosmin activates TBC1D3B by inhibiting the NF-κB signaling pathway. It blocks the activation of NF-κB, thereby reducing the expression of pro-inflammatory genes. This inhibition indirectly activates TBC1D3B by preventing NF-κB-mediated suppression. Thus, diosmin serves as an indirect activator of TBC1D3B through modulation of the NF-κB pathway. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein activates TBC1D3B by inhibiting the Wnt/β-catenin pathway. It disrupts the interaction between Wnt ligands and their receptors, leading to decreased β-catenin stabilization and transcriptional activity. This inhibition relieves the inhibitory effect of β-catenin on TBC1D3B, resulting in its activation. Therefore, baicalein acts as an indirect activator of TBC1D3B via modulation of the Wnt/β-catenin pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates TBC1D3B through inhibition of the mTOR signaling pathway. By directly inhibiting mTOR, quercetin reduces the phosphorylation of downstream targets, including S6K and 4EBP1. This inhibition of mTOR signaling alleviates the negative regulation of TBC1D3B, leading to its activation. Hence, quercetin acts as an indirect activator of TBC1D3B via the mTOR pathway. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates TBC1D3B by modulating the AMPK pathway. It stimulates AMPK activation, resulting in the inhibition of mTOR signaling. This inhibition relieves the suppressive effect of mTOR on TBC1D3B, thereby facilitating its activation. Consequently, EGCG indirectly activates TBC1D3B through AMPK-mediated regulation of the mTOR pathway. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein activates TBC1D3B through inhibition of the Wnt/β-catenin pathway. It disrupts the interaction between Wnt ligands and their receptors, leading to decreased β-catenin stabilization and transcriptional activity. This inhibition relieves the inhibitory effect of β-catenin on TBC1D3B, resulting in its activation. Therefore, genistein acts as an indirect activator of TBC1D3B via modulation of the Wnt/β-catenin pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates TBC1D3B by modulating the AMPK pathway. It activates AMPK, which inhibits mTOR signaling. This inhibition relieves the suppressive effect of mTOR on TBC1D3B, leading to its activation. Thus, resveratrol indirectly activates TBC1D3B through AMPK-mediated regulation of the mTOR pathway. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates TBC1D3B by modulating the Nrf2 pathway. It promotes the nuclear translocation of Nrf2, leading to increased expression of antioxidant enzymes. This activation indirectly stimulates TBC1D3B by enhancing cellular antioxidant defenses. Therefore, sulforaphane acts as an indirect activator of TBC1D3B through Nrf2-mediated regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates TBC1D3B by inhibiting the NF-κB signaling pathway. It blocks the activation of NF-κB, thereby reducing the transcription of inflammatory genes. This inhibition indirectly activates TBC1D3B by preventing NF-κB-mediated suppression. Thus, curcumin serves as an indirect activator of TBC1D3B through modulation of the NF-κB pathway. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin activates TBC1D3B by inhibiting the PI3K/Akt signaling pathway. It directly binds to and inhibits PI3K, leading to decreased Akt phosphorylation. This inhibition relieves the suppressive effect of Akt on TBC1D3B, allowing for its activation. Thus, luteolin indirectly activates TBC1D3B by modulating the PI3K/Akt pathway. | ||||||