MTHFD1L Activators
MTHFD1L activators are a class of chemical compounds that exert their influence on the enzyme Methylenetetrahydrofolate Dehydrogenase 1-Like (MTHFD1L), a key player in the folate metabolic pathway. These activators are characterized by their ability to modulate the activity of MTHFD1L, which plays a central role in one-carbon metabolism, a vital biochemical pathway essential for the synthesis of nucleotides, amino acids, and other important molecules within the cell. The MTHFD1L enzyme is primarily localized in the mitochondria, where it catalyzes the conversion of 10-formyltetrahydrofolate to 5,10-methylenetetrahydrofolate, a critical step in the transfer of one-carbon units for various biosynthetic processes.
MTHFD1L activators are designed to enhance the catalytic efficiency of the enzyme, promoting the flux of one-carbon units through the folate cycle. By doing so, these compounds have the potential to impact cellular processes that rely on one-carbon metabolism, including DNA synthesis, repair, and methylation, as well as the generation of essential cofactors like S-adenosylmethionine (SAM) and tetrahydrobiopterin (BH4). These activators may exhibit varying degrees of specificity towards MTHFD1L and could act through different mechanisms, such as allosteric modulation or direct interaction with the enzyme's active site.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
This natural polyphenol found in red grapes and other plants has been shown to activate MTHFD1L expression. Resveratrol has antioxidant and anti-inflammatory properties. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Derived from turmeric, curcumin is known for its anti-inflammatory and antioxidant properties. It has been reported to induce MTHFD1L expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid present in various fruits, vegetables, and grains. It has been suggested to activate MTHFD1L expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables like broccoli, sulforaphane is known for its chemoprotective properties. It has been associated with the induction of MTHFD1L activator expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a major polyphenol in green tea, known for its antioxidant properties. It has been reported to induce MTHFD1L activator expression, potentially linking green tea consumption to cellular processes. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folate is a crucial B-vitamin involved in one-carbon metabolism. Adequate folate levels are necessary for MTHFD1L activation, as it is directly tied to folate metabolism. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO is a solvent that has been found to induce MTHFD1L expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This nucleoside analog is used in epigenetic research and has been reported to induce MTHFD1L activator expression. It affects DNA methylation patterns and gene expression. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is an antioxidant and precursor to glutathione synthesis. It has been suggested to activate MTHFD1L expression, potentially contributing to its cellular effects. | ||||||