Integrin α8 Activators
The class of Integrin α8 activators constitutes a diverse assembly of chemicals that intricately regulate the activity of Integrin α8, a transmembrane receptor critically involved in essential cellular processes such as adhesion and migration. These activators, exhibiting a spectrum of direct and indirect mechanisms, collectively illuminate the complex and multifaceted regulatory networks orchestrating Integrin α8 activation. Direct activators within this class, exemplified by Cilengitide and A-770041, manifest their influence through distinct modes of interaction. Cilengitide, a cyclic peptide, acts as an antagonist of integrins, including Integrin α8, thereby impeding their interaction with extracellular matrix proteins. This interference translates into a modulation of integrin-mediated signaling pathways and an alteration of Integrin α8 activity, particularly in cellular processes like adhesion and migration. On the other hand, A-770041, a selective inhibitor of focal adhesion kinase (FAK), directly impacts Integrin α8-mediated cellular processes. By inhibiting FAK, a protein integral to integrin signaling, A-770041 exerts a direct influence on Integrin α8, affecting its role in cell adhesion and migration.
The realm of indirect activators encompasses compounds like Tanshinone IIA and YC-1, each targeting specific signaling pathways. Tanshinone IIA, found in Salvia miltiorrhiza, inhibits the TGF-β/Smad signaling pathway, which intersects with Integrin α8 signaling. This inhibition presents an indirect mechanism through which Integrin α8 activity may be modulated, shedding light on the intricate crosstalk between pathways governing cellular processes. The diverse mechanisms employed by Integrin α8 activators underscore the intricate regulation of Integrin α8, providing invaluable insights into strategies for manipulating its activity across diverse cellular contexts. As we deepen our understanding of the specific pathways influenced by these compounds, a clearer picture emerges of the complex networks governing Integrin α8 activation, offering a foundation for targeted interventions in conditions where Integrin α8 function plays a pivotal role.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Cilengitide is a cyclic peptide that acts as an antagonist of integrins, including Integrin α8. By binding to integrins, Cilengitide prevents their interaction with extracellular matrix proteins, influencing integrin-mediated signaling pathways and potentially modulating Integrin α8 activity. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $88.00 $316.00 | 22 | |
Tanshinone IIA is a bioactive compound found in Salvia miltiorrhiza. It has been shown to inhibit the TGF-β/Smad signaling pathway. As Integrin α8 is known to interact with TGF-β, Tanshinone IIA may indirectly influence Integrin α8 activity by modulating the TGF-β signaling cascade. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinases (ROCK). By inhibiting ROCK, Y-27632 influences actin cytoskeleton dynamics and cell contractility. As integrins are involved in cell adhesion and migration, the modulation of ROCK activity by Y-27632 may indirectly impact Integrin α8 function through alterations in cellular processes regulated by integrin-mediated signaling. | ||||||
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $102.00 $388.00 | 15 | |
SB-3CT is a matrix metalloproteinase (MMP) inhibitor, and it has been suggested that MMPs can influence integrin activity. By inhibiting MMPs, SB-3CT may indirectly affect Integrin α8 function, potentially modulating integrin-mediated processes such as cell adhesion and migration. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
EHop-016 is an inhibitor of Rac GTPase, a key regulator of cytoskeletal dynamics and cell migration. Since integrins are involved in cell adhesion and migration, the inhibition of Rac by EHop-016 may indirectly influence Integrin α8 activity by modulating the cytoskeletal rearrangements associated with integrin-mediated signaling pathways. | ||||||
YC-1 | 170632-47-0 | sc-202856 sc-202856A sc-202856B sc-202856C | 1 mg 5 mg 10 mg 50 mg | $33.00 $124.00 $218.00 $947.00 | 9 | |
YC-1 is an activator of soluble guanylyl cyclase (sGC), leading to increased levels of cGMP. As integrins can be modulated by cGMP signaling, YC-1 may indirectly influence Integrin α8 activity through the elevation of cGMP levels, potentially affecting integrin-mediated processes such as cell adhesion and migration. | ||||||
Bemcentinib | 1037624-75-1 | sc-507363 | 10 mg | $900.00 | ||
R428, also known as BGB324, is a selective inhibitor of Axl receptor tyrosine kinase. Integrins and receptor tyrosine kinases can collaborate in signaling events. Thus, the inhibition of Axl by R428 may indirectly modulate Integrin α8 activity by interfering with the crosstalk between Axl and integrin-mediated signaling pathways, potentially affecting cellular processes such as adhesion and migration. | ||||||