GGtase-α Activators
GGtase-α, which is involved in the prenylation of proteins, a post-translational modification critical for the proper localization and function of various intracellular proteins. GGtase-α, or geranylgeranyltransferase type I alpha subunit, typically works in conjunction with the beta subunit to attach geranylgeranyl groups to the C-terminus of target proteins. Prenylation by GGtase-α is particularly important for the function and signaling of small GTPases, which are involved in numerous cellular processes.
The specific activators of GGtase-α would need to facilitate its prenylation activity, possibly by increasing substrate availability, enhancing the enzyme's affinity for its substrates, or stabilizing the GGtase-α in a conformation that is more active. However, without further information or the provision of a gene name, it is not possible to generate a list of 12 specific chemical compounds that fit these criteria. Chemicals that could act as indirect activators would influence the pathways or cellular processes that regulate the function of GGtase-α or its substrate proteins.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Simvastatin is a competitive inhibitor of HMG-CoA reductase. By inhibiting this enzyme, simvastatin causes an increase in intracellular concentrations of isoprenoids that are substrates for GGtase-α, which could enhance the activity of GGtase-α by providing more substrate availability for prenylation of proteins. | ||||||
Geranylgeraniol | 24034-73-9 | sc-200858 sc-200858A | 20 mg 100 mg | $162.00 $474.00 | 14 | |
Geranylgeraniol is an intermediate in the mevalonate pathway and serves as a substrate for GGtase-α. Supplementing geranylgeraniol can increase the prenylation activity of GGtase-α by increasing the availability of its direct substrate. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $193.00 $838.00 | 2 | |
GGTI-298 is a selective inhibitor of GGtase-α. By transiently inhibiting GGtase-α, the subsequent removal of GGTI-298 can lead to a compensatory increase in GGtase-α activity, a phenomenon known as rebound hyperactivation. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene is a naturally occurring monoterpene that can increase the levels of isoprenoids by modulating the mevalonate pathway, which may secondarily enhance the activity of GGtase-α by increasing substrate availability. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $92.00 $256.00 | 5 | |
Zoledronic acid is a bisphosphonate that inhibits farnesyl diphosphate synthase in the mevalonate pathway. This inhibition can lead to the accumulation of upstream metabolites which may serve as substrates for GGtase-α, potentially enhancing its activity. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Manumycin A is a selective inhibitor of farnesyltransferase, another enzyme that uses FPP as a substrate. Inhibition of farnesyltransferase by Manumycin A could shunt more FPP towards GGtase-α, enhancing its activity. | ||||||
Squalene | 111-02-4 | sc-281155 sc-281155A sc-281155B | 10 ml 100 ml 500 ml | $49.00 $92.00 $215.00 | 1 | |
Squalene, a precursor in the cholesterol synthesis pathway, may indirectly enhance GGtase-α activity by modulating the levels of downstream isoprenoids that are substrates for GGtase-α. | ||||||
Farnesol | 4602-84-0 | sc-204748 sc-204748A | 50 ml 100 ml | $281.00 $374.00 | 2 | |
Farnesol is a direct product of the mevalonate pathway and a substrate for isoprenylation by GGtase-α. Providing exogenous farnesol could increase the activity of GGtase-α by increasing substrate availability. | ||||||