Cingulin Activators
Cingulin activators encompass a range of compounds that indirectly influence the functional dynamics of Cingulin through various cellular signaling pathways. These activators do not directly bind or modify Cingulin; instead, they exert their effects by modulating the cellular environment or signaling pathways that, in turn, affect Cingulin's role in tight junction assembly and function.
These chemicals act on diverse pathways such as adenylate cyclase activation, PKC modulation, MEK inhibition, PI3K inhibition, mTOR signaling, ROCK inhibition, p38 MAPK signaling, calcium signaling, EGFR pathway activation, glucocorticoid receptor modulation, and general inflammatory and oxidative stress pathways. The effects of these pathways converge on the regulation of cell junction dynamics, cytoskeletal organization, and cell polarity, all of which are crucial aspects of Cingulin's function. The modulation of these pathways leads to changes in tight junction assembly, cell adhesion, and barrier function, processes in which Cingulin plays a central role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. Elevated cAMP modulates tight junction assembly, influencing Cingulin's role in this process. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), modifying tight junction assembly and function, thereby influencing Cingulin activity indirectly. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Potent PKC inhibitor, affecting tight junction regulation and indirectly influencing Cingulin's role. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor, influencing actin dynamics and tight junction assembly, indirectly affecting Cingulin's function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, involved in cell growth and cytoskeletal organization, indirectly influencing Cingulin. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor, affecting actin cytoskeleton dynamics and potentially influencing Cingulin's role in tight junctions. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAPK, modulating inflammatory response and cellular stress pathways, which can indirectly affect Cingulin. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Calcium chelator, affecting calcium signaling pathways which can influence tight junction assembly and Cingulin function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid that modulates inflammation and cell adhesion processes, potentially affecting Cingulin's role in tight junctions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates various signaling pathways, including inflammatory and oxidative stress pathways, potentially influencing Cingulin. | ||||||