CDO Activators
Cysteine dioxygenase (CDO) is an essential enzyme in the metabolic pathway that catalyzes the conversion of cysteine into cysteine sulfinic acid, a critical step in the catabolism of sulfur-containing amino acids. This enzymatic activity is fundamental for the regulation of cysteine concentrations within the body, preventing the accumulation of cysteine to toxic levels and facilitating its utilization in various biochemical pathways, including the synthesis of taurine and sulfate. The enzyme thereby plays a pivotal role in maintaining cellular redox balance and in the synthesis of compounds that are vital for physiological processes such as neurotransmission, osmoregulation, and detoxification. The regulation of CDO activity is intricately linked to the sulfur amino acid metabolism, highlighting its significance in nutritional and metabolic homeostasis.
The activation of CDO involves several regulatory mechanisms that ensure its activity is modulated according to cellular cysteine levels and metabolic demands. One primary mechanism is the substrate-induced stabilization of the enzyme, where increasing concentrations of cysteine promote CDO's enzymatic activity by enhancing its structural stability and catalytic efficiency. This feedback mechanism ensures that cysteine catabolism is adjusted in response to its availability, thereby preventing the detrimental effects of its excess. Furthermore, post-translational modifications of CDO, such as phosphorylation, have been suggested to play a role in regulating its activity, influencing the enzyme's conformation and interaction with cofactors or substrates. These mechanisms of activation are crucial for the adaptive response of cells to variations in cysteine levels, enabling the precise control of sulfur amino acid metabolism and maintaining cellular and systemic health.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-Ketoglutaric Acid is a potential activator of CDO. It is an intermediate in the tricarboxylic acid (TCA) cycle and can enhance CDO activity by providing an additional substrate for the enzyme. By entering the TCA cycle, alpha-ketoglutaric acid influences the availability of metabolic intermediates, indirectly modulating CDO and promoting the conversion of cysteine to cysteine sulfinic acid. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $50.00 $110.00 $145.00 $248.00 $598.00 | 1 | |
Citric Acid is another TCA cycle intermediate that can act as a potential activator of CDO. By participating in cellular metabolism, citric acid contributes to the pool of metabolic intermediates, indirectly influencing CDO activity. The activation of CDO by citric acid is part of the intricate network of metabolic regulation, where the TCA cycle intersects with cysteine metabolism, leading to the enhanced conversion of cysteine to cysteine sulfinic acid. | ||||||
Oxaloacetic Acid | 328-42-7 | sc-279934 sc-279934A sc-279934B | 25 g 100 g 1 kg | $306.00 $963.00 $7980.00 | 1 | |
Oxaloacetic Acid, an intermediate in the TCA cycle, can potentially activate CDO. Similar to other TCA cycle intermediates, oxaloacetic acid modulates cellular metabolism, providing an additional substrate for CDO. Its role in promoting CDO activity highlights the interconnectedness of metabolic pathways, where TCA cycle intermediates play a crucial role in regulating the conversion of cysteine to cysteine sulfinic acid. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
Succinic Acid, a dicarboxylic acid, is a potential activator of CDO. It participates in the TCA cycle, influencing the cellular metabolic landscape. By providing an additional substrate for CDO, succinic acid indirectly enhances CDO activity. The activation of CDO by succinic acid is an example of how metabolic intermediates contribute to the regulation of cysteine metabolism, promoting the conversion of cysteine to cysteine sulfinic acid. | ||||||
Malic acid | 6915-15-7 | sc-257687 | 100 g | $130.00 | 2 | |
Malic Acid, another TCA cycle intermediate, is a potential activator of CDO. Its role in cellular metabolism involves influencing the pool of metabolic intermediates, indirectly modulating CDO activity. The activation of CDO by malic acid highlights the intricate crosstalk between different metabolic pathways, where TCA cycle intermediates play a regulatory role in promoting the conversion of cysteine to cysteine sulfinic acid. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $43.00 $57.00 $114.00 $228.00 | ||
Fumaric Acid, a key player in the TCA cycle, is a potential activator of CDO. Its involvement in cellular metabolism contributes to the pool of metabolic intermediates, indirectly influencing CDO activity. The activation of CDO by fumaric acid exemplifies the interconnected nature of metabolic regulation, where TCA cycle intermediates play a pivotal role in modulating the conversion of cysteine to cysteine sulfinic acid. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-Lipoic Acid is a potential activator of CDO. As a cofactor for various enzymes involved in cellular metabolism, including those in the TCA cycle, alpha-lipoic acid indirectly modulates CDO activity. Its role in cellular redox regulation and energy metabolism contributes to the activation of CDO, promoting the conversion of cysteine to cysteine sulfinic acid. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal Phosphate (PLP) is a potential activator of CDO. As an essential cofactor for a variety of enzymes, including those involved in amino acid metabolism, PLP indirectly modulates CDO activity. Its role in supporting enzymatic reactions contributes to the activation of CDO, promoting the conversion of cysteine to cysteine sulfinic acid. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic Acid, commonly known as Vitamin C, is a potential activator of CDO. Its role in cellular antioxidant defense and enzyme cofactor function indirectly influences CDO activity. By contributing to cellular redox balance and supporting enzymatic reactions, ascorbic acid promotes the activation of CDO, leading to an enhanced conversion of cysteine to cysteine sulfinic acid. T | ||||||
N-Acetyl-L-glutamic acid | 1188-37-0 | sc-228659 | 25 g | $72.00 | ||
N-Acetyl-L-glutamic acid, a cofactor in the urea cycle, is a potential activator of CDO. Its role in urea cycle regulation and nitrogen metabolism indirectly modulates CDO activity. By influencing metabolic pathways related to nitrogen metabolism, N-acetylglutamate contributes to the activation of CDO, promoting the conversion of cysteine to cysteine sulfinic acid. | ||||||