BUB3 Activators
BUB3 activators encompass a diverse group of chemicals that modulate BUB3 expression and activity, primarily through indirect mechanisms related to the spindle assembly checkpoint and cell cycle progression. BI-2536, AZD1152-HQPA, MLN8054, VX-680, and VX-689 indirectly activate BUB3 by targeting various components of the mitotic checkpoint, such as Aurora kinases and CDK1, disrupting proper cell cycle progression and leading to compensatory increases in BUB3 expression. Nocodazole, a microtubule destabilizer, induces mitotic arrest and activates BUB3 as a compensatory response to ensure proper spindle checkpoint function.
Furthermore, inhibitors like RO-3306 and GSK-461364, targeting CDK1 and PLK1, respectively, influence the G2/M and mitotic checkpoints, showcasing the interconnected regulatory network involving these kinases and BUB3. Additionally, WEE1 kinase inhibition by VX-689 and MK-5108 affects the G2/M checkpoint, indirectly activating BUB3. Compounds like ZM447439 and Barasertib, inhibiting Aurora kinases, disrupt spindle assembly checkpoint function, leading to compensatory BUB3 activation. The BUB3 activators collectively highlight the delicate balance in mitotic regulation, where perturbations in spindle assembly or cell cycle progression trigger compensatory mechanisms involving BUB3. Understanding the interplay between these chemicals and the intricate regulatory network involving BUB3 provides valuable insights into the molecular processes governing proper mitotic checkpoint function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI-2536, a PLK1 inhibitor, indirectly activates BUB3 by modulating the mitotic checkpoint. Inhibition of PLK1 by BI-2536 disrupts mitotic progression, leading to increased BUB3 expression as a compensatory response to maintain proper spindle checkpoint function. This indirect activation highlights the interplay between PLK1 and BUB3 in the regulation of mitosis. | ||||||
AZD1152-HQPA | 722544-51-6 | sc-265334 | 10 mg | $375.00 | ||
AZD1152-HQPA, an Aurora B inhibitor, indirectly activates BUB3 by affecting the spindle assembly checkpoint. Inhibition of Aurora B by AZD1152-HQPA disrupts proper chromosome segregation, leading to increased BUB3 expression as a compensatory mechanism to maintain spindle checkpoint integrity. This indirect activation underscores the regulatory role of Aurora B in BUB3 expression and function. | ||||||
MLN 8054 | 869363-13-3 | sc-484828 | 5 mg | $398.00 | ||
MLN8054, an Aurora A inhibitor, indirectly activates BUB3 by influencing the spindle assembly checkpoint. Inhibition of Aurora A by MLN8054 disrupts mitotic progression, leading to increased BUB3 expression as a compensatory response to maintain spindle checkpoint functionality. This indirect activation highlights the interplay between Aurora A and BUB3 in mitotic regulation. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
Tozasertib (VX-680), an Aurora kinase inhibitor, indirectly activates BUB3 by modulating the spindle assembly checkpoint. Inhibition of Aurora kinases by VX-680 disrupts proper chromosome segregation, leading to increased BUB3 expression as a compensatory mechanism to ensure the integrity of the spindle checkpoint. This indirect activation underscores the regulatory role of Aurora kinases in BUB3 expression and function. | ||||||
RO-3306 | 872573-93-8 | sc-358700 sc-358700A sc-358700B | 1 mg 5 mg 25 mg | $66.00 $163.00 $326.00 | 37 | |
RO-3306, a CDK1 inhibitor, indirectly activates BUB3 by influencing the G2/M checkpoint. Inhibition of CDK1 by RO-3306 disrupts proper cell cycle progression, leading to increased BUB3 expression as a compensatory response to maintain checkpoint integrity. This indirect activation highlights the interplay between CDK1 and BUB3 in the regulation of the G2/M checkpoint. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole, a microtubule destabilizer, indirectly activates BUB3 by disrupting mitotic spindle assembly. Treatment with Nocodazole induces mitotic arrest, leading to increased BUB3 expression as a compensatory response to ensure proper spindle checkpoint function. This indirect activation emphasizes the regulatory role of microtubules in BUB3 expression and the mitotic checkpoint. | ||||||
GSK461364 | 929095-18-1 | sc-364504 sc-364504A | 10 mg 50 mg | $500.00 $1540.00 | ||
GSK-461364, a PLK1 inhibitor, indirectly activates BUB3 by modulating the mitotic checkpoint. Inhibition of PLK1 by GSK-461364 disrupts mitotic progression, leading to increased BUB3 expression as a compensatory response to maintain proper spindle checkpoint function. This indirect activation highlights the interplay between PLK1 and BUB3 in the regulation of mitosis. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
MLN8237, an Aurora A inhibitor, indirectly activates BUB3 by influencing the spindle assembly checkpoint. Inhibition of Aurora A by MLN8237 disrupts mitotic progression, leading to increased BUB3 expression as a compensatory response to maintain spindle checkpoint functionality. This indirect activation highlights the interplay between Aurora A and BUB3 in the regulation of mitosis. | ||||||