ACOT9 Activators
Acyl-CoA thioesterase 9 (ACOT9) activators encompass a range of compounds that indirectly enhance the enzyme's activity by increasing the availability of its substrates or by modulating relevant metabolic pathways. These compounds typically act on different aspects of fatty acid metabolism. Compounds like AICA Ribonucleotide, which activates AMP-activated protein kinase, indirectly boost the enzymatic activity of ACOT9 by increasing fatty acid oxidation and thus the pool of acyl-CoA molecules.
PPARα agonists like WY-14643, bezafibrate, fenofibrate, clofibrate, and gemfibrozil induce the expression of genes involved in fatty acid oxidation, leading to an increase in acyl-CoA levels, which are substrates for ACOT9. The enhanced beta-oxidation of fatty acids due to the action of these compounds results in an elevated intracellular concentration of acyl-CoA molecules. L-Carnitine, while primarily known for its role in fatty acid transport into mitochondria, can also lead to a transient rise in acyl-CoA levels in the cytoplasm, which would be available for ACOT9 activity. These specific biochemical and cellular pathways that these compounds influence indirectly lead to the functional activation of ACOT9 by increasing the availability of acyl-CoA substrates.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Malonyl-CoA is a molecule that inhibits the carnitine palmitoyltransferase (CPT) system, leading to the accumulation of long-chain fatty acyl-CoAs in the cytoplasm. These acyl-CoAs are substrates for ACOT9, and their increased presence enhances the activity of the enzyme by providing more substrate molecules for hydrolysis. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICA Ribonucleotide (AICAR) activates AMP-activated protein kinase (AMPK), which can increase fatty acid oxidation and consequently the levels of acyl-CoA molecules. These molecules are substrates for ACOT9, therefore AICAR indirectly enhances the activity of ACOT9 by increasing the availability of its substrates. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
WY-14643 is a peroxisome proliferator-activated receptor alpha (PPARα) agonist that induces the expression of genes involved in fatty acid oxidation, which leads to an increase in acyl-CoA levels. Higher concentrations of acyl-CoA molecules provide more substrates for ACOT9, thereby indirectly enhancing its activity. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a fibric acid derivative that acts as an agonist for PPARs, including PPARα. It stimulates the beta-oxidation of fatty acids, thus increasing acyl-CoA levels in the cytoplasm. This increase in substrate availability indirectly enhances the activity of ACOT9. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate is a PPARα agonist that enhances the beta-oxidation pathway of fatty acids, resulting in increased levels of acyl-CoA. This increase indirectly enhances the activity of ACOT9 by providing a greater substrate pool for its enzymatic action. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Clofibrate is a PPARα agonist that stimulates the peroxisomal beta-oxidation of fatty acids, which indirectly enhances the activity of ACOT9 by leading to an accumulation of acyl-CoA molecules, the substrates that ACOT9 acts upon. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine facilitates the transport of long-chain fatty acids into mitochondria for beta-oxidation, which could lead to a transient increase in acyl-CoA levels in the cytoplasm as fatty acids shuttle between compartments. This transient increase may enhance the activity of ACOT9 by providing substrates for its enzymatic function. | ||||||