20S Proteasome α1 Activators
The chemical class of 20S Proteasome α1 activators encompasses a diverse set of compounds that modulate the function of the proteasome, a pivotal cellular machinery responsible for protein degradation. While direct activators specifically targeting 20S Proteasome α1 may not be well-defined, several compounds have been identified as indirect activators by influencing cellular processes associated with proteasome regulation. Proteasome inhibitors such as MG-132 and Epoxomicin disrupt the normal protein degradation process, causing the accumulation of ubiquitinated proteins. This accumulation induces an unfolded protein response (UPR), triggering cellular mechanisms that enhance the expression and activity of the proteasome, including 20S Proteasome α1. Similarly, ONX-0914, a selective inhibitor of immunoproteasomes, indirectly activate 20S Proteasome α1 by disrupting proteasome function and inducing the UPR.
Clasto-Lactacystin β-lactone, Betulinic Acid, Celastrol, Argyrin A, Triptolide, and Withaferin A contribute to proteasome activation by inducing proteasome assembly, upregulation, or inhibiting proteasome-associated deubiquitinases. These actions collectively enhance the clearance of misfolded proteins through the proteasomal degradation pathway, indirectly influencing 20S Proteasome α1 activity. Understanding the intricacies of these compounds' mechanisms provides insights into strategies for modulating 20S Proteasome α1 activity and, by extension, the broader proteasomal function. The delicate balance between proteasome activation and inhibition represents a crucial aspect of cellular homeostasis and underscores the complexity of cellular responses to proteotoxic stress. As research continues to unveil the nuances of proteasome regulation, these chemical modulators offer valuable tools for investigating the cellular pathways associated with 20S Proteasome α1 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that indirectly activates 20S Proteasome α1. By inhibiting the proteasome, it leads to the accumulation of ubiquitinated proteins, inducing an unfolded protein response (UPR) that triggers the upregulation and activation of the proteasome, including 20S Proteasome α1. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a natural product and irreversible proteasome inhibitor that can lead to the indirect activation of 20S Proteasome α1. Its impact on proteasomal function results in the accumulation of misfolded proteins, triggering cellular responses that enhance the activity of the proteasome, including 20S Proteasome α1. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Clasto-Lactacystin β-lactone is a specific and irreversible proteasome inhibitor. By disrupting normal proteasomal function, it induces an accumulation of misfolded proteins, triggering cellular responses that enhance the activity of the proteasome, including 20S Proteasome α1. | ||||||
ONX 0914 | 960374-59-8 | sc-477437 | 5 mg | $245.00 | ||
ONX-0914 is a selective immunoproteasome inhibitor. Through the inhibition of immunoproteasomes, ONX-0914 indirectly activates 20S Proteasome α1. This compound disrupts proteasomal function, leading to the accumulation of ubiquitinated proteins and subsequent upregulation of the proteasome system. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid is a natural compound that can induce proteasome activation, including 20S Proteasome α1. Its mechanism involves the induction of endoplasmic reticulum (ER) stress, leading to the unfolded protein response (UPR) and subsequent upregulation and activation of the proteasome, including 20S Proteasome α1. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol is a triterpene compound with anti-inflammatory properties that can indirectly activate 20S Proteasome α1. It induces heat shock response and upregulates proteasomal subunits, including 20S Proteasome α1. This activation enhances the clearance of misfolded proteins through the proteasomal degradation pathway. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a diterpenoid epoxide that can induce proteasome activation, including 20S Proteasome α1. Its mechanism involves the inhibition of proteasome-associated deubiquitinases (DUBs), leading to the accumulation of ubiquitinated proteins and subsequent upregulation and activation of the proteasome. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is a steroidal lactone that can activate the proteasome, including 20S Proteasome α1. Its mechanism involves the induction of proteasome assembly and upregulation, leading to enhanced proteasome activity. This compound promotes the clearance of misfolded proteins through the proteasomal degradation pathway. | ||||||