Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF24 (zinc finger protein 24), also known as ZNF191, KOX17, ZSCAN3 or RSG-A, is a 368 amino acid nuclear protein that belongs to the Krüppel C2H2-type zinc-finger protein family. Expressed in tissues throughout the body with the exception of heart, ZNF24 functions as a transcriptional repressor for a variety of proteins, such as VEGF (vascular endothelial growth factor), and is thought to be important for early embryonic development and cell proliferation. ZNF24 contains four C2H2-type zinc fingers and one SCAN box domain and, upon DNA damage, may be phosphorylated by ATM or ATR.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ZNF24 (25-G) | sc-101079 | 100 µg/ml | $333.00 |