ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
XLF (XRCC4-like factor), also known as non-homologous end-joining factor 1 (NHEJ1) or cernunnos, is a 295 amino acid protein belonging to the XLF family. There are two main repair pathways for DNA double-strand breaks: homologous recombination (HR) and non-homologous end-joining (NHEJ). In the latter pathway, the Ku-70/Ku-86 heterodimer binds the DNA ends together and the DNA-PK catalytic subunits are recruited. Then the DNA ends are processed by DNA processing enzymes, such as Artemis. The binding is finalized through DNA Ligase IV, which acts in a complex with XRCC4 and XLF to stabilize the repair. Thus, it is believed that XLF interacts with DNA Ligase IV and XRCC4 to constitute the enzymatic core of the NHEJ machinery. Two named isoforms of XLF exist as a result of alternative splicing events.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps XLF (E-2) | sc-393844 | 200 µg/ml | $316.00 | |||
XLF (E-2): m-IgG Fc BP-HRP Kit | sc-538321 | 200 µg Ab; 10 µg BP | $354.00 | |||
XLF (E-2): m-IgGκ BP-HRP Kit | sc-535905 | 200 µg Ab; 40 µg BP | $354.00 | |||
XLF (E-2): m-IgG1 BP-HRP Kit | sc-545639 | 200 µg Ab; 20 µg BP | $354.00 | |||
Anticorps XLF (E-2) X | sc-393844 X | 200 µg/0.1 ml | $316.00 |