
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. VEZF1 (vascular endothelial zinc finger 1), also known as ZNF161 or DB1, is a nuclear localizing zinc-finger protein belonging to the Krüppel C2H2-type zinc-finger family. Expressed throughout the body with the highest level of expression found in the kidneys and skeletal muscle, VEZF1 is an endothelial transcription factor that regulates ET-1 (endothelin-1) promoter expression. Through its interaction with the CT/GC-rich region of the ET-1 promoter, VEZF1 helps to regulate proper assembly of the cardiovascular system during early development by activating the expression of various genes found in the vascular endothelium.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps VEZF1 (ZNF5J141) | sc-81134 | 100 µg/ml | $333.00 |