VAMP-1/2 Antibody (4E240): sc-58309
- VAMP-1/2 Antibody (4E240) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against synaptic vesicle containing fractions immunoprecipitated from human brain homogenates
- recommended for detection of VAMP-1 and VAMP-2 of mouse, rat, human, bovine, porcine and Xenopus origin by WB and IP
- m-IgGκ BP-HRP is the preferred secondary detection reagent for VAMP-1/2 Antibody (4E240) for WB applications. This reagent is now offered in a bundle with VAMP-1/2 Antibody (4E240) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
VAMP-1/2 Antibody (4E240) is a mouse monoclonal IgM antibody that detects VAMP-1/2 in mouse, rat, human, bovine, and porcine samples through western blotting (WB) and immunoprecipitation (IP) applications. VAMP-1 and VAMP-2, also known as vesicle-associated membrane proteins, play a crucial role in the process of exocytosis, which is essential for neurotransmitter release and various cellular signaling pathways. These proteins are primarily located on the membranes of synaptic vesicles and are vital for the fusion of these vesicles with the presynaptic membrane, facilitating the release of neurotransmitters into the synaptic cleft. The interaction of VAMPs with syntaxins and SNAPs is critical for the formation of the SNARE complex, which drives membrane fusion. Disruption of this process can lead to significant neurological disorders, highlighting the importance of VAMP-1 and VAMP-2 in maintaining proper synaptic function. Anti-VAMP-1/2 antibody (4E240) serves as an invaluable tool for researchers studying the mechanisms of exocytosis and its implications in various physiological and pathological conditions.
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VAMP-1/2 Antibody (4E240) References:
- The role of synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction. | Liu, Y., et al. 2011. J Physiol. 589: 1603-18. PMID: 21282288
- Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy. | Ferecskó, AS., et al. 2015. Brain Struct Funct. 220: 1013-29. PMID: 24442865
- Distribution of SNAP25, VAMP1 and VAMP2 in mature and developing deep cerebellar nuclei after estrogen administration. | Manca, P., et al. 2014. Neuroscience. 266: 102-15. PMID: 24534378
- Calcineurin/NFAT signaling represses genes Vamp1 and Vamp2 via PMCA-dependent mechanism during dopamine secretion by Pheochromocytoma cells. | Kosiorek, M., et al. 2014. PLoS One. 9: e92176. PMID: 24667359
- Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. | Peng, L., et al. 2014. PLoS Pathog. 10: e1004177. PMID: 25010769
- VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins. | Gómez-Jaramillo, L., et al. 2018. Cell Mol Immunol. 15: 353-366. PMID: 27616736
- Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons. | Hoogstraaten, RI., et al. 2020. Sci Rep. 10: 10913. PMID: 32616842
- VAMPs sensitive to tetanus toxin are required for cortical granule exocytosis in mouse oocytes. | de Paola, M., et al. 2021. Exp Cell Res. 405: 112629. PMID: 34023392
- The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins. | Ballin, M., et al. 2023. FEBS J. 290: 2320-2337. PMID: 36047592
- Isolation and characterization of a dual prenylated Rab and VAMP2 receptor. | Martincic, I., et al. 1997. J Biol Chem. 272: 26991-8. PMID: 9341137
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VAMP-1/2 Antibody (4E240) | sc-58309 | 200 µg/ml | $322.00 | |||
VAMP-1/2 Antibody (4E240): m-IgGκ BP-HRP Bundle | sc-550735 | 200 µg Ab; 40 µg BP | $361.00 |