Anticorps uricase (F-7): sc-166070

In most mammals, urate oxidase (uricase) is present in liver, with little or no detectable activity in other tissues. It is associated with the peroxisomes and exists as a tetramer. Humans and certain primates lack this enzyme, which catalyzes the oxidation of uric acid to allantoin. The human Lesch-Nyhan syndrome is a rare neurological and behavioral disorder caused by an inherited deficiency in the level of activity of the purine salvage enzyme hypoxanthine-guanosine phosphoribosyl transferase (HPRT). The identification of mice with complete HPRT deficiency but without any symptoms of the Lesch-Nyhan syndrome raises the possibility that the absence of uricase activity in the purine metabolism pathway may contribute to the development of the neurologic symptoms observed in humans. Comparison of the sequences in man, mouse and pig suggested that loss of uricase function in man was due to a sudden mutational event. The gene which encodes uricase maps to human chromosome 1p22.

L'anticorps uricase préféré est l'Anticorps uricase (C-11): sc-166214.