The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TTC12 (tetratricopeptide repeat domain 12), also known as TPARM, is a 705 amino acid cytoplasmic protein containing a TPR repeat domain and three armadillo repeat motifs. TTC12 is expressed in testis, prostate, lung, germinal center B cells, neuroblastoma, teratocarcinoma, colon cancer and gastric cancer. The gene encoding TTC12 is located in a region of human chromosome 11 that is commonly deleted in a variety of cancers, therefore, it is considered a candidate tumor suppressor gene. Human chromosome 11 houses over 1,400 genes and comprises nearly 4% of the human genome.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TTC12 (C-9) | sc-393493 | 200 µg/ml | $316.00 | |||
TTC12 (C-9): m-IgG Fc BP-HRP Kit | sc-538231 | 200 µg Ab; 10 µg BP | $354.00 | |||
TTC12 (C-9): m-IgGκ BP-HRP Kit | sc-535801 | 200 µg Ab; 40 µg BP | $354.00 | |||
TTC12 (C-9): m-IgG1 BP-HRP Kit | sc-545592 | 200 µg Ab; 20 µg BP | $354.00 | |||
TTC12 (C-9) peptide neutralisant | sc-393493 P | 100 µg/0.5 ml | $68.00 |