ACCÈS RAPIDE AUX LIENS
The tRNA-splicing endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5′ and 3′ splice sites, thereby releasing introns and free tRNA molecules with 2′,3′ cyclic phosphates and 5′-OH termini. In addition to its role in pre-tRNA splicing, the heterotetrameric endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. TSEN54 (tRNA splicing endonuclease 54 homolog), also known as HsSEN54 (SEN54 homolog) or tRNA-intron endonuclease Sen54, is a 526 amino acid protein belonging to the SEN54 family. Localizing to nucleus, TSEN54 is a member of a complex which identifies and cleaves the splice sites in pre-tRNA, and may also be involved in mRNA processing. Defects in TSEN54 may result in pontocerebellar hypoplasia (PCH) type 4 and 2A, characterized by structural abnormalities to the cerebellum, inferior olive, and ventral pons. TSEN54 exists as two alternatively spliced isoforms.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TSEN54 (A-9) | sc-398327 | 200 µg/ml | $316.00 | |||
TSEN54 (A-9): m-IgGκ BP-HRP Kit | sc-536031 | 200 µg Ab; 40 µg BP | $354.00 | |||
TSEN54 (A-9): m-IgG2b BP-HRP Kit | sc-549505 | 200 µg Ab; 10 µg BP | $354.00 | |||
TSEN54 (A-9) peptide neutralisant | sc-398327 P | 100 µg/0.5 ml | $68.00 |