TRPC6 Antibody (B-10): sc-515837
- TRPC6 Antibody (B-10) is a mouse monoclonal IgG1 κ TRPC6 antibody, cited in 11 publications, provided at 200 µg/ml
- raised against amino acids 546-590 mapping within an extracellular domain of TRPC6 of human origin
- TRPC6 Antibody (B-10) is recommended for detection of TRPC6 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TRPC6 Antibody (B-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRPC6 Antibody (B-10) for WB applications. These reagents are now offered in bundles with TRPC6 Antibody (B-10) (see ordering information below).
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TRPC6 Antibody (B-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRPC6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRPC6 Antibody (B-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The transient receptor potential cation channel 6 (TRPC6) plays a crucial role in mediating store-operated calcium entry, which is essential for various cellular functions, including muscle contraction, neurotransmitter release, and cell proliferation. TRPC6 is primarily located in the plasma membrane of cells in tissues such as the placenta, spleen, lung, small intestine, and ovary, where TRPC6 facilitates the influx of calcium ions in response to diacylglycerol activation. TRPC6 consists of 931 amino acids and is part of a larger superfamily of TRP channels that are vital for maintaining calcium homeostasis and responding to physiological stimuli. The gene encoding human TRPC6 is located on chromosome 11q21-q22, and TRPC6 function is critical for various signaling pathways, making TRPC6 a significant target for research in cardiovascular and neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRPC6 Antibody (B-10) References:
- From worm to man: three subfamilies of TRP channels. | Harteneck, C., et al. 2000. Trends Neurosci. 23: 159-66. PMID: 10717675
- Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. | Hofmann, T., et al. 2000. J Mol Med (Berl). 78: 14-25. PMID: 10759026
- The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. | Inoue, R., et al. 2001. Circ Res. 88: 325-32. PMID: 11179201
- TRPC1, a human homolog of a Drosophila store-operated channel. | Wes, PD., et al. 1995. Proc Natl Acad Sci U S A. 92: 9652-6. PMID: 7568191
- Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. | Zhu, X., et al. 1995. FEBS Lett. 373: 193-8. PMID: 7589464
- Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. | Zitt, C., et al. 1996. Neuron. 16: 1189-96. PMID: 8663995
- A novel capacitative calcium entry channel expressed in excitable cells. | Philipp, S., et al. 1998. EMBO J. 17: 4274-82. PMID: 9687496
- Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-->q22. | D'Esposito, M., et al. 1998. Cytogenet Cell Genet. 83: 46-7. PMID: 9925922
- Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. | Hofmann, T., et al. 1999. Nature. 397: 259-63. PMID: 9930701
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRPC6 Antibody (B-10) | sc-515837 | 200 µg/ml | $322.00 | |||
TRPC6 Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-531536 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRPC6 Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-525248 | 200 µg Ab, 40 µg BP | $361.00 | |||
TRPC6 Antibody (B-10) AC | sc-515837 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TRPC6 Antibody (B-10) HRP | sc-515837 HRP | 200 µg/ml | $322.00 | |||
TRPC6 Antibody (B-10) FITC | sc-515837 FITC | 200 µg/ml | $336.00 | |||
TRPC6 Antibody (B-10) PE | sc-515837 PE | 200 µg/ml | $349.00 | |||
TRPC6 Antibody (B-10) Alexa Fluor® 488 | sc-515837 AF488 | 200 µg/ml | $364.00 | |||
TRPC6 Antibody (B-10) Alexa Fluor® 546 | sc-515837 AF546 | 200 µg/ml | $364.00 | |||
TRPC6 Antibody (B-10) Alexa Fluor® 594 | sc-515837 AF594 | 200 µg/ml | $364.00 | |||
TRPC6 Antibody (B-10) Alexa Fluor® 647 | sc-515837 AF647 | 200 µg/ml | $364.00 | |||
TRPC6 Antibody (B-10) Alexa Fluor® 680 | sc-515837 AF680 | 200 µg/ml | $364.00 | |||
TRPC6 Antibody (B-10) Alexa Fluor® 790 | sc-515837 AF790 | 200 µg/ml | $364.00 |