TRP1 Antibody (B-2): sc-514900

TRP1 Antibody (B-2) is a mouse monoclonal IgG2b antibody that detects TRP1 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRP1, or tyrosinase-related protein 1, plays a crucial role in the melanin biosynthesis pathway, specifically in the production of eumelanin, which is essential for pigmentation in hair, skin, and eyes. TRP1 is primarily located in the melanosomes of melanocytes, where TRP1 works in concert with other enzymes, including tyrosinase and TRP2, to facilitate the conversion of tyrosine to melanin. Proper localization of TRP1 within the melanosomal membrane is vital, as such positioning ensures efficient interaction with its substrate and other melanin-synthesizing enzymes, thereby influencing the overall pigmentation process. Mutations or deficiencies in TRP1 can lead to pigmentation disorders, highlighting TRP1′s importance in maintaining normal skin and hair color. Anti-TRP1 antibody (B-2) serves as an invaluable tool for researchers studying melanin synthesis and related disorders, providing insights into the molecular mechanisms underlying pigmentation and potential therapeutic targets.

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TRP1 Antibody (B-2) References:

1. Expression of tyrosinase, TRP-1 and TRP-2 in ultraviolet-irradiated human melanomas and melanocytes: TRP-2 protects melanoma cells from ultraviolet B induced apoptosis.  |  Nishioka, E., et al. 1999. Melanoma Res. 9: 433-43. PMID: 10596909
2. Transcriptional activation of tyrosinase and TRP-1 by p53 links UV irradiation to the protective tanning response.  |  Nylander, K., et al. 2000. J Pathol. 190: 39-46. PMID: 10640990
3. The role of phosphoinositide 3-kinase in the sorting and transport of newly synthesized tyrosinase-related protein-1 (TRP-1).  |  Chen, H., et al. 2001. J Investig Dermatol Symp Proc. 6: 105-14. PMID: 11764278
4. Characterization of TRP-1 mRNA levels in dominant and recessive mutations at the mouse brown (b) locus.  |  Jackson, IJ., et al. 1990. Genetics. 126: 451-9. PMID: 2245917
5. Conformational studies of human Des-Trp1,Nle12-minigastrin in water-trifluoroethanol mixtures by 1H NMR and circular dichroism.  |  Mammi, S., et al. 1988. Biochemistry. 27: 1374-9. PMID: 3365393
6. Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs.  |  Jimbow, K., et al. 1994. Pigment Cell Res. 7: 311-9. PMID: 7886004
7. Human TRP-1 has tyrosine hydroxylase but no dopa oxidase activity.  |  Zhao, H., et al. 1994. Pigment Cell Res. 7: 131-40. PMID: 7971745
8. Role of gene expression and protein synthesis of tyrosinase, TRP-1, lamp-1, and CD63 in UVB-induced melanogenesis in human melanomas.  |  Hara, H., et al. 1994. J Invest Dermatol. 102: 495-500. PMID: 8151127
9. TRP-1 expression correlates with eumelanogenesis in human pigment cells in culture.  |  del Marmol, V., et al. 1993. FEBS Lett. 327: 307-10. PMID: 8348959
10. DOPA-negative melanocytes in the outer root sheath of human hair follicles express premelanosomal antigens but not a melanosomal antigen or the melanosome-associated glycoproteins tyrosinase, TRP-1, and TRP-2.  |  Horikawa, T., et al. 1996. J Invest Dermatol. 106: 28-35. PMID: 8592077

The preferred TRP1 antibody is TRP1 Antibody (TA99): sc-58438.