transferrin Antibody (11D3): sc-52256

Transferrin Antibody (11D3) is a mouse monoclonal IgG1 antibody that detects transferrin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-transferrin antibody (11D3) is available in a non-conjugated form, specifically designed for transferrin detection. Transferrin plays a crucial role in iron metabolism, serving as the primary iron transport protein in vertebrate serum. Transferrin binds to free iron ions and facilitates their transport to various tissues, including the bone marrow, where iron is utilized for hemoglobin synthesis in erythrocytes. Transferrin consists of two homologous lobes, each containing a high-affinity iron-binding site, which allows for efficient iron sequestration and delivery. Transferrin is predominantly synthesized in the liver, but is also produced in smaller quantities in the testis and brain, where transferrin acts as an important marker for oligodendrocyte differentiation. Transferrin internalization occurs via interaction with the transferrin receptor (TfR), also known as CD71, which is critical for cellular iron uptake. Following iron release, transferrin is recycled back into the extracellular space, highlighting transferrin′s role in iron reutilization. Deficiencies or mutations in the transferrin gene can lead to atransferrinemia, a rare genetic disorder characterized by microcytic anemia and excessive iron accumulation, underscoring transferrin′s importance in iron regulation and overall health.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

transferrin Antibody (11D3) References:

1. Transferrin oversaturation.  |  Strobos, J., et al. 1999. Am J Kidney Dis. 34: 401-2. PMID: 10465728
2. Transferrin/transferrin receptor-mediated drug delivery.  |  Li, H. and Qian, ZM. 2002. Med Res Rev. 22: 225-50. PMID: 11933019
3. Glutaminolysis and Transferrin Regulate Ferroptosis.  |  Gao, M., et al. 2015. Mol Cell. 59: 298-308. PMID: 26166707
4. The transferrin isoforms in chronic hepatitis.  |  Gruszewska, E., et al. 2017. Clin Biochem. 50: 1131-1135. PMID: 28673788
5. Transferrin and transferrin receptors update.  |  Kawabata, H. 2019. Free Radic Biol Med. 133: 46-54. PMID: 29969719
6. Transferrin Enhances Microglial Phagocytic Capacity.  |  Carden, TR., et al. 2019. Mol Neurobiol. 56: 6324-6340. PMID: 30758712
7. Transferrin Receptors in Erythropoiesis.  |  Richard, C. and Verdier, F. 2020. Int J Mol Sci. 21: PMID: 33352721
8. Transferrin-induced thrombosis in hypoxia.  |  Cooper, S. 2022. Blood. 140: 2006-2008. PMID: 36355465
9. Transferrin Enhances Neuronal Differentiation.  |  Pérez, MJ., et al. 2023. ASN Neuro. 15: 17590914231170703. PMID: 37093743
10. Transferrin metabolism and the liver.  |  Aisen, P. 1984. Semin Liver Dis. 4: 193-206. PMID: 6385268

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-transferrin Antibody (11D3) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-transferrin Antibody (11D3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

transferrin Antibody (11D3) Specifications

Alternate Product Name: TF (transferrin)

Product Clone Name: 11D3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: transferrin

Epitope Species: human

Product Reactivity/Detection: transferrin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for transferrin Antibody (11D3): N/A

The preferred transferrin antibody is transferrin Antibody (D-9): sc-365871.