Anticorps TPO (B-10): sc-398525
- L'Anticorps TPO (B-10) est un monoclonal de souris mouse IgG2b κ (chaîne légère kappa) fourni en 200 µg/ml
- spécifique d'un épitope situé entre les acides aminés 329-356 au niveau C-terminus de TPO d'origine mouse
- recommandé pour la détection de presursor and mature TPO of mouse, rat human origin and galectin-9 of human origin par WB, IP, IF et ELISA
- 2b BP-HRP">m-IgG2b BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps TPO (B-10) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps TPO (B-10)(voir les informations relatives à la commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
Thrombopoietin (TPO or THPO), also known as c-Mpl ligand (c-Mpl L), is a cytokine that plays a central role in megakaryopoiesis by influencing the development and maturation of megakaryocytes and platelet production. TPO is expressed by both mature and progenitor megakaryocytes, as well as by human platelets. Human TPO cDNA encodes a 332 amino acid precursor with a 21 amino acid signal peptide which is cleaved to generate the mature protein. TPO isolated from serum ranges in molecular weight, which suggests that the protein is highly glycosylated. TPO exerts its biological effects through the TPO receptor, c-Mpl. Stimulation of c-Mpl with TPO results in the activation of the Janus tyrosine kinase family members, Tyk 2 and JAK2 which in turn phosphorylate Stat5 and Stat3, causing their nuclear translocation and the transcription of Stat responsive genes. The gene encoding TPO maps to human chromosome 3q26.3-q27.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TPO (B-10) | sc-398525 | 200 µg/ml | $316.00 | |||
TPO (B-10): m-IgGκ BP-HRP Kit | sc-536086 | 200 µg Ab; 40 µg BP | $354.00 | |||
TPO (B-10): m-IgG2b BP-HRP Kit | sc-549513 | 200 µg Ab; 10 µg BP | $354.00 | |||
TPO (B-10) peptide neutralisant | sc-398525 P | 100 µg/0.5 ml | $68.00 |