Members of the TLX homeobox gene family are expressed in the developing hindbrain; specifically, the TLX3 gene is expressed in the developing dorsal and ventral medulla oblongata. The TLX3 gene is required for formation of first-order relay visceral sensory neurons in the brainstem. Development of most nor/adrenergic centers is compromised in both TLX3- and Phox2b-deficient mice. The TLX3 and Phox2 proteins have independent functions in specifying the nor/adrenergic phenotype. TLX3-deficient newborn mice have a high rate of respiration, a decreased duration of inspiration and frequent apnea; they die shortly after birth from central respiratory failure. In both chick and mouse embryos, TLX3 expression occurs in two longitudinal stripes of postmitotic neurons in the developing hindbrain and spinal cord. Implicated in T-ALL (T-cell acute lymphoblastic leukemia), the t(5:14)(q35;q32) translocation increases transcription of the TLX3 gene.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TLX3 (34-L) | sc-81990 | 100 µg/ml | $333.00 |