TICAM-1, also known as Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule, maps at chromosome 19p13.3. It can physically bind the TIR domain of Toll-like receptor 3 (TLR3) and activate the IFN-beta promoter. TLR proteins are signaling molecules that can recognize pathogen associated molecular patterns and may function as a link between the innate and adaptive immune responses. TICAM-1 mediates dsRNA-TLR3-dependent production of IFN-beta. This TICAM-1-dependent pathway is important for other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response. TICAM-2, a cytoplasmic protein, physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TLR4 signaling to TICAM-1, which in turn activates IRF-3. In its structural features, TICAM-2 resembles Mal/TIRAP, an adapter that links TLR2/4 and MyD88.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TICAM-2 (G-6) | sc-376356 | 200 µg/ml | $316.00 | |||
TICAM-2 (G-6): m-IgG Fc BP-HRP Kit | sc-540551 | 200 µg Ab; 10 µg BP | $354.00 | |||
TICAM-2 (G-6): m-IgG1 BP-HRP Kit | sc-542199 | 200 µg Ab; 20 µg BP | $354.00 |