In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that are required for transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH; and sequence-specific factors that regulate gene expression. The basal transcription factors and Pol II form a specific multiprotein complex near the transcription start site by interacting with core promotor elements such as the TATA box generally located 25-30 base pairs upstream of the transcription start site. Human TFIIE consists of two subunits, α and β. The structure of TFIIE appears to be a heterotetramer (α2β2); both subunits are required for optimal basal-level transcription.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TFIIE-α (F-2) | sc-133065 | 200 µg/ml | $316.00 | |||
Anticorps TFIIE-α (F-2) X | sc-133065 X | 200 µg/0.1 ml | $316.00 |