TEL2 Antibody (F-8): sc-376137

TEL2 Antibody (F-8) is a mouse monoclonal IgG2a antibody that detects TEL2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TEL2, also known as ETV7, TREF, or TELB, is a 341 amino acid nuclear protein that plays a crucial role in regulating gene expression as a transcriptional repressor. TEL2 contains one PNT domain and one Ets DNA-binding domain, which are essential for binding to specific DNA sequences, particularly the motif 5′-CCGGAAGT-3′. TEL2′s ability to modulate transcription is vital for maintaining normal cellular processes, and TEL2 expression is predominantly observed in hematopoietic tissues. Defects in the TEL2 gene have been linked to B-cell malignancies, highlighting TEL2′s significant role in carcinogenesis. Alternative splicing of the TEL2 gene results in seven isoforms (designated A-G), which may have distinct regulatory functions and implications in various biological contexts. Anti-TEL2 antibody (F-8) is an invaluable tool for researchers investigating the molecular mechanisms underlying hematopoietic malignancies and the broader implications of Ets family proteins in cancer biology.

The preferred TEL2 antibody is TEL2 Antibody (E-1): sc-374478.