Anticorps TCF-3 (F-5): sc-398640
- L'Anticorps TCF-3 (F-5) est un monoclonal de souris mouse IgG1 κ (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 421-575 de TCF-3 d'origine mouse
- recommandé pour la détection de TCF-3 d'origine mouse, rat et human par WB, IP, IF et ELISA
- Réactifs TransCruz pour une application en ChIP (sc-398640 X, 200 µg/0.1 ml)
- Voir TCF-3 (E-2): sc-166411 pour d'autres anticorps conjugués TCF-3, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- Le m-IgG Fc BP-HRP et le m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps TCF-3 (F-5) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps TCF-3 (F-5)(voir les informations relatives à la commande ci-dessous).
The TCF/LEF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. The TCF (T cell factor) proteins are required during developmental pathways. TCF-1 is essential for lymphoid cell development, while two other members, TCF-3 and TCF-4, are implicated in the development of the central nervous system. The Wnt mediated signaling pathway induces cytosolic β-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The β-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates β-catenin and, in turn, increases the degradation of cytosolic β-catenin to, thereby, inhibit the activity of TCF proteins. Mutations in the APC gene, which are commonly observed in colorectal carcinomas, disrupt this regulatory pathway and correlate with an accumulation of β-catenin and the increased activation of the TCF target genes.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TCF-3 (F-5) | sc-398640 | 200 µg/ml | $316.00 | |||
TCF-3 (F-5): m-IgG Fc BP-HRP Kit | sc-538487 | 200 µg Ab; 10 µg BP | $354.00 | |||
TCF-3 (F-5): m-IgGκ BP-HRP Kit | sc-536111 | 200 µg Ab; 40 µg BP | $354.00 | |||
Anticorps TCF-3 (F-5) X | sc-398640 X | 200 µg/0.1 ml | $316.00 |