Anticorps TCEA1 (G-5): sc-393439

Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II (Pol II) and several basal transcription factors to form the preinitiation complex (PIC). After initiation, promotor-specific contacts between the PIC and Pol II are disrupted, thus allowing elongation (a process regulated by Pol II and several proteins called elongation factors) to begin. TCEA1(Transcription elongation factor A protein 1), also known as TFIIS or SII, is an elongation factor that is essential for proper elongation past DNA arresting sites. When template-encoded arresting sites trap elongating RNA polymerases, the transcription complex becomes locked, preventing efficient elongation. TCEA1 binds to Pol II and functions to cleave the nascent transcript, thereby unlocking the complex and allowing transcription to continue. Localized to the nucleus, TCEA1 contains three independently-folding domains, all of which are necessary for proper binding to Pol II. Defects in the gene encoding TCEA1 are implicated in salivary gland pleiomorphic adenomas, which are the most common form of benign epithelial tumors of the salivary gland.

L'anticorps TCEA1 préféré est l'Anticorps TCEA1 (B-6): sc-393520.