ACCÈS RAPIDE AUX LIENS
Tandem PH (pleckstrin homology) domain-containing protein 2 (TAPP2) is a widely expressed cytoplasmic adaptor protein related to BAM32. Highest expression levels of TAPP2 are found in heart and kidney tissues. Upon growth factor stimulation and activation of phosphoinositol 3-kinase, TAPP2 is recruited to the plasma membrane and accumulates in F-Actin-rich membrane ruffles. This recruitment occurs through the specific interaction of the TAPP2 C-terminal PH domain with phosphotidylinositol 3,4-bisphosphate. TAPP2 is positively regulated by Fc g RII and SHIP. The overexpression of TAPP2 increases NFAT-dependent transcriptional activation after G cell Ag receptor ligation and increases the sustained phase of the calcium response. TAPP2 may play a role in the activation of B and T cells.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TAPP2 (C-8) | sc-271307 | 200 µg/ml | $316.00 | |||
TAPP2 (C-8): m-IgG Fc BP-HRP Kit | sc-537607 | 200 µg Ab; 10 µg BP | $354.00 | |||
TAPP2 (C-8): m-IgGκ BP-HRP Kit | sc-534922 | 200 µg Ab; 40 µg BP | $354.00 | |||
TAPP2 (C-8): m-IgG2b BP-HRP Kit | sc-549892 | 200 µg Ab; 10 µg BP | $354.00 | |||
TAPP2 (C-8) peptide neutralisant | sc-271307 P | 100 µg/0.5 ml | $68.00 |