Anticorps splicing factor 1 (E-9): sc-365269

Mammalian splicing factor 1 (designated SF1, zinc finger protein 162, ZFM1, CW17R and mammalian branch point binding protein [mBBP]) specifically recognizes the seven-nucleotide branch point sequence located at 3′ splice sites and participates in the assembly of early spliceosomal complexes. Splicing factor 1 functions as a transcriptional repressor and may control both proliferation and expression of pro-inflammatory gene products in smooth muscle cells. In addition, cytokine-induced downregulation of splicing factor 1 expression may contribute to the pathogenesis of hyperproliferative inflammatory diseases. The structure of splicing factor 1 contains a nuclear transport domain, a metal binding motif, and glutamine- and proline-rich regions. Human splicing factor 1 also exists as several different isoforms, H1-isoform and Bo-isoform, produced by alternative splicing events. The human splicing factor 1 gene is located on chromosome 11 close to the gene encoding Menin, the gene responsible for multiple endocrine neoplasia-type 1 (MEN1).

L'anticorps splicing factor 1 préféré est l'Anticorps splicing factor 1 (H-9): sc-398881.