spectrin beta III Antibody (4D9): sc-293284
- spectrin β III Antibody (4D9) is a mouse monoclonal IgG3 κ provided at 100 µg/ml
- raised against a partial recombinant protein mapping within amino acids 643-720 of spectrin β III of human origin
- recommended for detection of spectrin β III of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for spectrin β III Antibody (4D9). This work is in progress.
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spectrin β III Antibody (4D9) is a mouse monoclonal IgG3 antibody that detects spectrin β III in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Spectrin β III plays a crucial role in maintaining the structural integrity of the cytoskeleton, particularly within the Golgi apparatus and vesicular membranes, where spectrin β III contributes to the organization and stability of these cellular structures. Spectrin β III is essential for proper intracellular transport and communication, as spectrin β III helps to anchor membrane proteins and facilitates the movement of vesicles, thereby influencing various cellular processes such as secretion and signal transduction. Notably, spectrin β III is highly expressed in the brain, kidney, pancreas, and liver, highlighting spectrin β III′s importance in these organs′ cellular architecture and function. The unique structural properties of spectrin β III, including spectrin β III′s ability to form dimers and higher-order oligomers, allow effective interaction with other cytoskeletal components, ensuring the resilience and adaptability of the cellular framework. Anti-spectrin β III antibody (4D9) is an invaluable tool for researchers studying the dynamics of the cytoskeleton and its implications in health and disease.
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spectrin beta III Antibody (4D9) References:
- Monitoring the expression profiles of doxorubicin-resistant K562 human leukemia cells by serial analysis of gene expression. | Ichikawa, Y., et al. 2004. Int J Hematol. 79: 276-82. PMID: 15168598
- Advances and perspectives of the architecture of hemidesmosomes: lessons from structural biology. | de Pereda, JM., et al. 2009. Cell Adh Migr. 3: 361-4. PMID: 19736524
- β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations. | Clarkson, YL., et al. 2014. Hum Mol Genet. 23: 3875-82. PMID: 24603075
- A human β-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding. | Avery, AW., et al. 2016. Sci Rep. 6: 21375. PMID: 26883385
- β-III-spectrin spinocerebellar ataxia type 5 mutation reveals a dominant cytoskeletal mechanism that underlies dendritic arborization. | Avery, AW., et al. 2017. Proc Natl Acad Sci U S A. 114: E9376-E9385. PMID: 29078305
- β-III-spectrin immunohistochemistry as a potential diagnostic tool with high sensitivity for malignant peripheral nerve sheath tumors. | Hirbe, AC., et al. 2018. Neuro Oncol. 20: 858-860. PMID: 29596596
- SPTBN2, a New Biomarker of Lung Adenocarcinoma. | Wu, C., et al. 2021. Front Oncol. 11: 754290. PMID: 34745988
- Early-phase drug discovery of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia type 5. | Guhathakurta, P., et al. 2023. J Biol Chem. 299: 102956. PMID: 36731793
- Increased Actin Binding Is a Shared Molecular Consequence of Numerous SCA5 Mutations in β-III-Spectrin. | Atang, AE., et al. 2023. Cells. 12: PMID: 37626910
- Molecular consequences of SCA5 mutations in the spectrin-repeat domains of β-III-spectrin. | Denha, SA., et al. 2024. bioRxiv.. PMID: 39345584
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
spectrin β III Antibody (4D9) | sc-293284 | 100 µg/ml | $322.00 |