SOTS-1 (CAS 223507-96-8)
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Superoxide radical anion is a toxic by-product of mitochondrial respiration that is formed from approximately 1-4% of the oxygen metabolized by aerobic organisms. SOTS-1 is an azo-compound that can be thermally decomposed in aqueous solution to create superoxide radical anion at a constant, controlled rate. More specifically, SOTS-1 thermally decomposes to form an intermediate that reacts with oxygen at the diffusion-controlled limit to generate superoxide radical anion. The decay of SOTS-1 into the intermediate follows first order kinetics, and exhibits a half-life of 4900 seconds at physiological pH and temperature.1,2 This allows for study of the effect of superoxide on biologically relevant systems in a controlled environment that closely mimics conditions in vivo.
SOTS-1 (CAS 223507-96-8) References
1 Konya, K.G., Paul, T., Lin, S., et al. Laser flash photolysis studies on the first superoxide thermal source. First direct measurements of the rates of solvent-assisted 1,2-hydrogen atom shifts and a proposed new mechanism for this unusual rearrangement. J Am Chem Soc 122 7518-7527 (2000). 2 Ingold, K.U., Paul, T., Young, M.J., et al. Invention of the first azo compound to serve as a superoxide thermal source under physiological conditions: Concept, synthesis, and chemical properties. J Am Chem Soc 119 12364-12365 (1997).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SOTS-1, 500 µg | sc-205511 | 500 µg | $37.00 | |||
SOTS-1, 1 mg | sc-205511A | 1 mg | $52.00 | |||
SOTS-1, 5 mg | sc-205511B | 5 mg | $225.00 | |||
SOTS-1, 10 mg | sc-205511C | 10 mg | $375.00 |