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T lymphocytes express several low molecular mass transmembrane adaptor proteins that recruit SH2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling pathways. One such protein, SIT (SHP2 interacting transmembrane adaptor protein) is a disulfide-linked homodimeric glycoprotein that is expressed in lymphocytes. SIT is reduced to half its molecular mass via endoglycosidase treatment. It contains five potential tyrosine phosphorylation sites, suggesting a role in TCR-mediated recruitment of SH2 domain-containing intracellular signaling molecules to the plasma membrane. SIT interacts with SHP2 and also with the adaptor protein Grb2. In addition, it is a substrate for the Src protein kinases Fyn, Lck and ZAP-70.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SIT (G-8) | sc-271202 | 200 µg/ml | $316.00 | |||
SIT (G-8): m-IgG Fc BP-HRP Kit | sc-537587 | 200 µg Ab; 10 µg BP | $354.00 | |||
SIT (G-8): m-IgGκ BP-HRP Kit | sc-534893 | 200 µg Ab; 40 µg BP | $354.00 | |||
SIT (G-8): m-IgG1 BP-HRP Kit | sc-545246 | 200 µg Ab; 20 µg BP | $354.00 |