Two families of mammalian lectin-like adhesion molecules bind glycoconjugate ligands in a sialic acid-dependent manner: the selectins and the sialoadhesins. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members recognizing sialylated ligands. Siglec-5 binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. There exist four isoforms of hSiglec-5 possessing three (hSiglec-5-3L and -3C) or four (hSiglec-5-4L and -4S) extracellular domains linked to long (hSiglec-5-3L and -4L) or short (hSiglec-5-4S) cytoplasmic tails or existing as a soluble isoform (hSiglec-5-3C). Siglec-5 is expressed by monocytes and neutrophils, but is absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec-5 may play a role in the diagnosis and monitoring of acute myeloid leukemia (AML). Siglec-14 is predominantly expressed in hematopoietic tissues but is also found in lung and testis.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Siglec-5/14 (C-2) | sc-374584 | 200 µg/ml | $316.00 | |||
Siglec-5/14 (C-2): m-IgG Fc BP-HRP Kit | sc-540481 | 200 µg Ab; 10 µg BP | $354.00 | |||
Siglec-5/14 (C-2): m-IgG1 BP-HRP Kit | sc-542151 | 200 µg Ab; 20 µg BP | $354.00 | |||
Siglec-5/14 (C-2) peptide neutralisant | sc-374584 P | 100 µg/0.5 ml | $68.00 |