Anticorps Shigatoxin (STX-3): sc-69867
- L'Anticorps Shigatoxin (STX-3) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre Shigatoxin d'origine E. coli
- recommandé pour la détection de Shigatoxin par WB
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire Shigatoxin (STX-3). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
ACCÈS RAPIDE AUX LIENS
Hemolytic uremic syndrome (HUS) is the number one cause of acute renal failure in children worldwide. HUS is characterized by microangiopathic hemolytic anemia, a low platelet count, and diarrhea. Shigatoxins (Stxs) produced by Shigella dysenteriae type 1 and enterohemorrhagic Escherichia coli are the most common cause of HUS. Shigatoxin 1 (Stx1) is an Escherichia coli protein that increases arachidonate release and eicosanoid production in glomerular epithelial cells, thereby inhibiting protein synthesis. It also increases cytokine release by renal epithelial cells. Proximal tubule inflammatory cytokine production is stimulated by Stx1, which also stimulates IL-6 mRNA accumulation when it is overexpressed. Brain injury in HUS is related to Stx1 binding to globotriaosylceramide. Inhibition of p38 MAPK significantly reduces the inflammatory cytokine up-regulation of Stx-receptor synthesis and cell-surface expression, thereby decreasing Stx cytotoxicity.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Shigatoxin (STX-3) | sc-69867 | 200 µg/ml | $316.00 |