Anticorps SgK223 (O67): sc-130491
- L'Anticorps SgK223 (O67) est un monoclonal de souris IgG2a κ, cité dans 1 publications, fourni en 100 µg/ml
- élevé contre Pragmine recombinante d'origine human.
- recommandé pour la détection de SgK223 d'origine human par IF et IHC(P)
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire SgK223 (O67). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its role in signal transduction pathways and high frequency of mutations in human malignancies. The founding members of the Ras family (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The mammalian Rho proteins (Rho A, B, C, 6, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Three Rho-related GTPases Rnd1 (Rho 6), Rnd2 (Rho 7), and Rnd3 (Rho 8 or Rho E) form a distinct branch of the Rho family since they differ from other Rho proteins in size, charge, and biochemical properties. Rnd proteins are likely to be farnesylated, and appear to be constitutively in the activated GTP-bound form. Rnd proteins act as negative regulators of Actin assembly and of cell adhesion. Rnd2 binds to SgK223 (sugen kinase 223) in a GTP-dependent manner. Rnd2-bound SgK223 stimulates Rho A activity and induces cell contraction to regulate neurite outgrowth.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps SgK223 (O67) | sc-130491 | 100 µg/ml | $333.00 |