SERCA3 Antibody (PL/IM430): sc-81759

SERCA3 Antibody (PL/IM430) is a mouse monoclonal IgG1 kappa light chain antibody that detects SERCA3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-SERCA3 antibody (PL/IM430) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SERCA3, a member of the sarcoplasmic or endoplasmic reticulum calcium ATPase family, plays a crucial role in calcium homeostasis by mediating Ca2+ uptake into intracellular stores, essential for various cellular functions, including muscle relaxation and signaling pathways. Unlike SERCA1 and SERCA2, which are primarily expressed in muscle tissues, SERCA3 is predominantly found in non-muscle cells such as platelets, lymphoid cells, and mast cells, highlighting its importance in immune responses and cellular signaling. Alternative splicing of SERCA3, along with interactions with other calcium signaling proteins, underscores its potential role in various physiological and pathological processes. SERCA3 monoclonal antibody (PL/IM430) enables researchers to gain valuable insights into calcium regulation dynamics in diverse biological contexts.

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SERCA3 Antibody (PL/IM430) References:

1. Aberrant SERCA3 expression is closely linked to pathogenesis, invasion, metastasis, and prognosis of gastric carcinomas.  |  Xu, XY., et al. 2012. Tumour Biol. 33: 1845-54. PMID: 22948776
2. VDAC1 and SERCA3 Mediate Progesterone-Triggered Ca2+ Signaling in Breast Cancer Cells.  |  Azeez, JM., et al. 2018. J Proteome Res. 17: 698-709. PMID: 29185755
3. NAADP/SERCA3-Dependent Ca2+ Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation.  |  Feng, M., et al. 2020. Circ Res. 127: e166-e183. PMID: 32588751
4. Role of SERCA3 in the Prognosis and Immune Function in Pan-Cancer.  |  Li, J., et al. 2022. J Oncol. 2022: 9359879. PMID: 36385955
5. Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.  |  Adle-Biassette, H., et al. 2024. Pathology. 56: 343-356. PMID: 38184384
6. The SERCA3-type of organellar Ca2+ pumps.  |  Wuytack, F., et al. 1995. Biosci Rep. 15: 299-306. PMID: 8825032
7. Expression of two isoforms of the third sarco/endoplasmic reticulum Ca2+ ATPase (SERCA3) in platelets. Possible recognition of the SERCA3b isoform by the PL/IM430 monoclonal antibody.  |  Bobe, R., et al. 1998. FEBS Lett. 423: 259-64. PMID: 9512369
8. Calcium ATPase and respiratory muscle function.  |  Aubier, M. and Viires, N. 1998. Eur Respir J. 11: 758-66. PMID: 9596133
9. Characterization of the 3' end of the mouse SERCA 3 gene and tissue distribution of mRNA spliced variants.  |  Ozog, A., et al. 1998. FEBS Lett. 427: 349-52. PMID: 9637255
10. Enhanced myocardial contractility and increased Ca2+ transport function in transgenic hearts expressing the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase.  |  Loukianov, E., et al. 1998. Circ Res. 83: 889-97. PMID: 9797337
11. Cellular distribution of Ca2+ pumps and Ca2+ release channels in rat cardiac hypertrophy induced by aortic stenosis.  |  Anger, M., et al. 1998. Circulation. 98: 2477-86. PMID: 9832495
12. Functional characterization of alternatively spliced human SERCA3 transcripts.  |  Poch, E., et al. 1998. Am J Physiol. 275: C1449-58. PMID: 9843705

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SERCA3 Antibody (PL/IM430) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-SERCA3 Antibody (PL/IM430) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SERCA3 Antibody (PL/IM430) Specifications

Alternate Product Name: SERCA3

Product Clone Name: PL/IM430

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: SERCA3

Epitope Species: human

Product Reactivity/Detection: SERCA3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for SERCA3 Antibody (PL/IM430): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, L: Azide-Free, PE: Phycoerythrin

The preferred SERCA1/2/3 antibody is SERCA1/2/3 Antibody (B-7): sc-271669.