Molecular structure of SD-169, CAS Number: 1670-87-7
SD-169 (CAS 1670-87-7)
Alternate Names:
5-Carboxamidoindole
Application:
SD-169 is a selective inhibitor of p38α and p38β
CAS Number:
1670-87-7
Purity:
98%
Molecular Weight:
160.2
Molecular Formula:
C9H8N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SD-169 inhibits p38alpha MAPK and acts as an ATP competitive inhibitor of p38 kinase. Reports indicate that in T cells of the pancreatic beta islets, SD-169 decreases the expression of p38 and HSP60, and has also been shown to decrease insulitis and beta cell death in NOD mice. p38 MAPK plays an important role in the regulation of inflammatory cytokine production and T cell function. SD-169 is an inhibitor of p38beta.
SD-169 (CAS 1670-87-7) References
- Inhibition of p38 MAP kinase activity enhances axonal regeneration. | Myers, RR., et al. 2003. Exp Neurol. 184: 606-14. PMID: 14769353
- Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. | Medicherla, S., et al. 2006. J Pharmacol Exp Ther. 318: 99-107. PMID: 16603672
- Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration. | Tzvetkov, NT. and Antonov, L. 2017. J Enzyme Inhib Med Chem. 32: 960-967. PMID: 28726524
Inhibitor of:
cathepsin G, p38, p38 alpha, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SD-169, 10 mg | sc-200693 | 10 mg | $59.00 | |||
SD-169, 50 mg | sc-200693A | 50 mg | $169.00 |