SCP-3 Antibody (25): sc-136064
- SCP-3 Antibody (25) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1-109 of SCP-3 of rat origin
- recommended for detection of SCP-3 of mouse, rat, human and canine origin by WB and IP
- See SCP-3 (D-1): sc-74569 for SCP-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SCP-3 Antibody (25). This work is in progress.
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SCP-3 Antibody (25) is a mouse monoclonal IgG1 antibody that detects SCP-3 in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). SCP-3 plays a crucial role in the formation of synaptonemal complexes, which are essential for proper chromosome pairing and recombination during meiotic prophase. SCP-3 is primarily located in the nucleus of testicular meiotic prophase cells and primordial germ cells, where SCP-3 contributes to the structural integrity of sister chromatid cohesion during mammalian meiosis I. SCP-3 is vital for ensuring accurate chromosome segregation, as SCP-3 facilitates the alignment and pairing of homologous chromosomes, thereby preventing aneuploidy and ensuring genetic stability in gametes. SCP-3 is characterized by a C-terminal coiled-coil domain, which promotes homotypic interactions, further underscoring SCP-3′s importance in the assembly and function of synaptonemal complexes. Notably, SCP-3 is first detected in leptotene-stage spermatocytes and is absent in late meiotic cells, highlighting SCP-3′s dynamic expression pattern during meiosis. With specific reactivity and critical role in meiosis, anti-SCP-3 antibody (25) is an invaluable tool for researchers studying reproductive biology and chromosomal dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SCP-3 Antibody (25) References:
- The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. | Yuan, L., et al. 2000. Mol Cell. 5: 73-83. PMID: 10678170
- Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3. | Yuan, L., et al. 2002. Science. 296: 1115-8. PMID: 12004129
- E2F1 deficiency impairs murine spermatogenesis and augments testicular degeneration in SCP3-nullizygous mice. | Hoja, MR., et al. 2004. Cell Death Differ. 11: 354-6. PMID: 14685160
- Involvement of the cohesin Rad21 and SCP3 in monopolar attachment of sister kinetochores during mouse meiosis I. | Parra, MT., et al. 2004. J Cell Sci. 117: 1221-34. PMID: 14970259
- Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries. | Bukovsky, A., et al. 2008. Cell Cycle. 7: 683-6. PMID: 18256545
- Expression, crystallization and preliminary X-ray crystallographic studies of SCP3 coiled-coil domain. | Seo, EK., et al. 2013. Acta Crystallogr Sect F Struct Biol Cryst Commun. 69: 1281-3. PMID: 24192369
- Synaptonemal complex protein 3 is a prognostic marker in cervical cancer. | Cho, H., et al. 2014. PLoS One. 9: e98712. PMID: 24905095
- Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis. | Kitano, H., et al. 2017. J Transl Med. 15: 138. PMID: 28623914
- Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3-NANOG Axis. | Oh, SJ., et al. 2018. Cancer Res. 78: 2638-2653. PMID: 29437706
- Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression. | Oh, SJ., et al. 2021. Int J Mol Sci. 22: PMID: 34445562
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCP-3 Antibody (25) | sc-136064 | 50 µg/0.5 ml | $322.00 |